| Name | TGFalpha |
|---|---|
| Synonyms | EGF like TGF; ETGF; TFGA; TGF alpha; TGF type 1; TGFA; TGFalpha; Transforming growth factor alpha… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9920428 | Piva TJ, Francis KG, Krause DR, Chojnowski GM, Ellem KA: Effect of UV irradiation on cell surface protease activity and amino acid uptake. Mutat Res. 1998 Nov 9;422(1):55-67. We previously found that UVC irradiation stimulates the release of TGFalpha from its membrane-bound preprocursor form whereby it acts as a stimulus to rapid, reparative cell multiplication; clearly this runs the risk hastening mitosis before UV-induced DNA damage is fully corrected, which in turn may increase the likelihood of residual lesions persisting and hence of new mutations being generated. |
1(0,0,0,1) | Details |
| 17702527 | Coe KJ, Jia Y, Ho HK, Rademacher P, Bammler TK, Beyer RP, Farin FM, Woodke L, Plymate SR, Fausto N, Nelson SD: Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening. Chem Res Toxicol. 2007 Sep;20(9):1277-90. Epub 2007 Aug 17. A nitro to cyano analogue of FLU (CYA) was synthesized and used to test this hypothesis in the TGFalpha-transfected mouse hepatocyte cell line (TAMH). Comparisons of transcriptomic changes caused by FLU with those caused by a panel of known cytotoxicants tetrafluoroethylcysteine, diquat, and rotenone (ROT)] indicated that FLU results in a temporal gene expression pattern similar to ROT, a known inhibitor of complex I of the electron transport chain. |
1(0,0,0,1) | Details |