| Name | glucose transporter 1 |
|---|---|
| Synonyms | Erythrocyte/hepatoma glucose transporter; GLUT; GLUT 1; GLUT1; Glucose transporter 1; HepG2 glucose transporter; SLC2A1; Glucose transporter 1s… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10780954 | Lin Z, Weinberg JM, Malhotra R, Merritt SE, Holzman LB, Brosius FC 3rd: GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation. . Am J Physiol Endocrinol Metab. 2000 May;278(5):E958-66. Similar protection against cell death and apoptosis was seen in GLUT-1-overexpressing cells treated for 6 h with the electron transport inhibitor rotenone. |
166(2,2,2,6) | Details |
| 11713226 | Becker C, Sevilla L, Tomas E, Palacin M, Zorzano A, Fischer Y: The endosomal compartment is an insulin-sensitive recruitment site for GLUT4 and GLUT1 transporters in cardiac myocytes. Endocrinology. 2001 Dec;142(12):5267-76. Rotenone recruited GLUT4 and GLUT1 to the cell surface from endosomal pool 2 without affecting pool 1. |
115(1,2,2,5) | Details |
| 7841183 | Wheeler TJ, Fell RD, Hauck MA: Translocation of two transporters in heart: effects of rotenone, uncouplers, workload, insulin and anoxia. Biochim Biophys Acta. 1994 Dec 30;1196(2):191-200. Our previous studies on the acute regulation of transport in perfused rat hearts were extended to explore further the mechanism of regulation by anoxia; to test the effects of a transport inhibitor; and to compare the translocation of two transporter isoforms (GLUT1 and GLUT4). |
2(0,0,0,2) | Details |
| 19091749 | Liu Y, Veena CK, Morgan JB, Mohammed KA, Jekabsons MB, Nagle DG, Zhou YD: Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways. J Biol Chem. 2009 Feb 27;284(9):5859-68. Epub 2008 Dec 17. At the concentrations that in hibited HIF-1 activation, compound 2 inhibited hypoxic induction of HIF-1 target genes (CDKN1A, GLUT-1, and VEGF), tumor angiogenesis in vitro, cell migration, and chemotaxis. Mechanistic studies indicate that, unlike rotenone and other mitochondrial inhibitors, compound 2 represents the first small molecule that inhibits HIF-1 activation by simultaneously suppressing mitochondrial respiration and disrupting protein translation in vitro. |
1(0,0,0,1) | Details |
| 12062197 | Agani FH, Pichiule P, Carlos Chavez J, LaManna JC: Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells. Comp Biochem Physiol A Mol Integr Physiol. 2002 May;132(1):107-9. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 transporter. Because mitochondria have been postulated to be involved in the regulation of HIF-1, we tested the effects of mitochondrial electron transport chain complex I inhibitors, rotenone and 1-methyl-4-phenylpiridinium (MPP (+)), on hypoxic-induced accumulation of HIF-1 alpha, the regulated component of the dimer. |
1(0,0,0,1) | Details |
| 7493931 | Ebert BL, Firth JD, Ratcliffe PJ: Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem. 1995 Dec 8;270(49):29083-9. An enhancer lying 5' to the mouse Glut-1 gene was found to convey responses both to hypoxia and to the mitochondrial inhibitors, azide and rotenone. |
34(0,1,1,4) | Details |
| 8447373 | Bashan N, Burdett E, Guma A, Sargeant R, Tumiati L, Liu Z, Klip A: Mechanisms of adaptation of transporters to changes in the oxidative chain of muscle and fat cells. Am J Physiol. 1993 Feb;264(2 Pt 1):C430-40. DNP and rotenone elevated the content of GLUT-1 protein in isolated plasma membranes and decreased it in intracellular light microsomes, suggestive of translocation of this transporter isoform. |
34(0,1,1,4) | Details |
| 16195374 | KC S, Carcamo JM, Golde DW: enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. FASEB J. 2005 Oct;19(12):1657-67. Loading mitochondria with AA quenched mitochondrial ROS and inhibited oxidative mitochondrial DNA damage. mtAA inhibited oxidative stress resulting from rotenone-induced disruption of the mitochondrial respiratory chain and prevented mitochondrial membrane depolarization in response to a protonophore, CCCP. |
2(0,0,0,2) | Details |
| 11435296 | Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ: Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood. 2001 Jul 15;98(2):296-302. Furthermore, concentrations of rotenone that maximally inhibited respiration did not affect HIF activation by hypoxia. To test this model the induction of the HIF-1alpha subunit and the HIF target gene, glucose-transporter-1, was examined in a variety of mutant cells that lacked mitochondrial DNA (rho0) or had other genetic defects in mitochondrial respiration. |
1(0,0,0,1) | Details |