| Name | Potassium channel (protein family or complex) |
|---|---|
| Synonyms | Potassium channel |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15795934 | Yang Y, Liu X, Long Y, Wang F, Ding JH, Liu SY, Sun YH, Yao HH, Wang H, Wu J, Hu G: Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats. J Neurosci Res. 2005 May 1;80(3):442-9. Our previous studies revealed that iptakalim, a novel ATP-sensitive potassium channel opener, has a significant neuroprotective function against ischemia in vivo or rotenone-induced neurotoxicity in vitro. |
94(1,1,3,4) | Details |
| 15987402 | Wood DM, Alsahaf H, Streete P, Dargan PI, Jones AL: Fatality after deliberate ingestion of the pesticide rotenone: a case report. Crit Care. 2005 Jun;9(3):R280-4. Epub 2005 Apr 29. In vitro cell studies have shown that rotenone-induced toxicity is reduced by the use of antioxidants and potassium channel openers. |
81(1,1,1,1) | Details |
| 16257489 | Liu X, Wu JY, Zhou F, Sun XL, Yao HH, Yang Y, Ding JH, Hu G: The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells. Neurosci Lett. 2006 Feb 13;394(2):131-5. Epub 2005 Oct 28. |
81(1,1,1,1) | Details |
| 17356569 | Zhou F, Wu JY, Sun XL, Yao HH, Ding JH, Hu G: Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation. Neuropsychopharmacology. 2007 Dec;32(12):2570-80. Epub 2007 Mar 14. In the present study, we demonstrated that systematic administration with iptakalim (IPT), an (ATP)-sensitive potassium channel (K (ATP)) opener, could alleviate rotenone-induced degeneration of dopaminergic neurons in rat substantia nigra along with the downregulation of microglial activation and mRNA levels of tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2). |
31(0,1,1,1) | Details |
| 18801963 | Garciarena CD, Caldiz CI, Correa MV, Schinella GR, Mosca SM, Chiappe de Cingolani GE, Cingolani HE, Ennis IL: Na+/H+ exchanger-1 inhibitors decrease myocardial production via direct mitochondrial action. J Appl Physiol. 2008 Dec;105(6):1706-13. Epub 2008 Sep 18. The mitochondria appeared to be the source of the NOX-dependent ROS released by the "ROS-induced ROS release mechanism" that was blunted by the mitochondrial ATP-sensitive potassium channel blockers 5-hydroxydecanoate and glibenclamide, inhibition of complex I of the electron transport chain with rotenone, and inhibition of the permeability transition pore (MPTP) by cyclosporin A. |
31(0,1,1,1) | Details |
| 15927086 | Yang Y, Liu X, Long Y, Wang F, Ding JH, Liu SY, Sun YH, Yao HH, Wang H, Wu J, Hu G: Activation of mitochondrial ATP-sensitive channels improves rotenone-related motor and neurochemical alterations in rats. Int J Neuropsychopharmacol. 2006 Feb;9(1):51-61. Epub 2005 Jun 1. The aim of the present study is to examine the potential therapeutic effects of iptakalim, an ATP-sensitive potassium-channel opener, and diazoxide, a selective mitochondrial ATP-sensitive potassium-channel opener, on Parkinsonian symptoms in rats induced by rotenone. |
7(0,0,1,2) | Details |
| 15265589 | Yang Y, Liu X, Ding JH, Sun J, Long Y, Wang F, Yao HH, Hu G: Effects of iptakalim on rotenone-induced cytotoxicity and release from PC12 cells. Neurosci Lett. 2004 Aug 5;366(1):53-7. In the present study, the neuroprotective effect of iptakalim, a novel ATP-sensitive potassium channel opener, was studied against rotenone-induced cytotoxicity in rat dopaminergic PC12 cells. |
7(0,0,1,2) | Details |
| 8670305 | Wojtczak L, Nikitina ER, Czyz A, Skulskii IA: Cuprous ions activate glibenclamide-sensitive potassium channel in liver mitochondria. Biochem Biophys Res Commun. 1996 Jun 14;223(2):468-73. |
2(0,0,0,2) | Details |
| 16725203 | Kou J, Klorig DC, Bloomquist JR: Potentiating effect of the ATP-sensitive potassium channel blocker glibenclamide on complex I inhibitor neurotoxicity in vitro and in vivo. Neurotoxicology. 2006 Sep;27(5):826-34. Epub 2006 Apr 28. We measured the ability of mitochondrial inhibitors of complexes I (rotenone, MPP (+), and HPP (+)), II (amdro), IV (Na and an uncoupler (dinoseb) to release preloaded from murine striatal synaptosomes. |
1(0,0,0,1) | Details |
| 12210849 | Tai KK, Truong DD: Activation of -sensitive channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson's disease. J Neurosci Res. 2002 Aug 15;69(4):559-66. The degree of protection is in proportion to the bouts of exposure to an ATP-sensitive potassium channel opener, a feature reminiscent of ischemic tolerance in vivo. |
1(0,0,0,1) | Details |
| 14681995 | Tkachenko HM, Kurhaliuk NM, Vovkanych LS: [Role of ATP-sensitive potassium channel activators in liver mitochondrial function in rats with different resistance to hypoxia]. Ukr Biokhim Zh. 2003 Sep-Oct;75(5):69-76. Additional analyses contain the next inhibitors: mitochondrial fermentative complex I-10 mkM rotenone, succinate dehydrogenase 2 mM |
1(0,0,0,1) | Details |
| 17261694 | Pastore D, Trono D, Laus MN, Di Fonzo N, Flagella Z: Possible plant mitochondria involvement in cell adaptation to drought stress. J Exp Bot. 2007;58(2):195-210. Durum wheat mitochondria may act against chloroplast/cytosol over-reduction: the / antiporter and the rotenone-insensitive external NAD (P) H dehydrogenases allow cytosolic NAD (P) H oxidation; under stress this may occur without high ROS production due to co-operation with AOX, which is activated by intermediates of the photorespiratory cycle. Durum wheat mitochondria possess three energy-dissipating systems: the ATP-sensitive plant mitochondrial potassium channel (PmitoK (ATP)); the plant uncoupling protein (PUCP); and the alternative oxidase (AOX). |
1(0,0,0,1) | Details |
| 2791223 | Haworth RA, Goknur AB, Berkoff HA: Inhibition of ATP-sensitive channels of adult rat heart cells by antiarrhythmic drugs. Circ Res. 1989 Oct;65(4):1157-60. Treatment of cells with rotenone plus p-trifluoromethoxyphenylhydrazone (FCCP) rapidly depleted ATP levels and strongly stimulated the rate of 86Rb uptake. We conclude that 1) the stimulated 86Rb uptake is measuring ATP-sensitive potassium channel activity, 2) the ATP-sensitive potassium channel is strongly inhibited by quinidine, and amiodarone, and 3) this inhibition may contribute to the antiarrhythmic action of these drugs. |
1(0,0,0,1) | Details |
| 15143528 | Tkachenko HM, Moibenko OO, Kurhaliuk NM: [Effect of ATP-sensitive potassium channel modulators and intermittent hypoxia on mitochondrial respiration during stress]. Ukr Biokhim Zh. 2003 Nov-Dec;75(6):115-22. We used next substrates of oxidation--0.35 mM 1 mM alpha-ketoglutarate, 3 mM 3 mM 2.5 mM and inhibitor of the mitochondrial fermentative complex I (10 microM rotenone), succinate dehydrogenase inhibitor (2 mM and inhibitor of transamination (1 mM aminooxiacetate). |
1(0,0,0,1) | Details |
| 12603842 | Tai KK, McCrossan ZA, Abbott GW: Activation of mitochondrial ATP-sensitive channels increases cell viability against rotenone-induced cell death. J Neurochem. 2003 Mar;84(5):1193-200. |
0(0,0,0,0) | Details |
| 17615104 | Varas R, Wyatt CN, Buckler KJ: Modulation of TASK-like background channels in rat arterial chemoreceptor cells by intracellular ATP and other nucleotides. J Physiol. 2007 Sep 1;583(Pt 2):521-36. Epub 2007 Jul 5. All of these stimuli act in a similar manner, i.e. by inhibiting a background TASK-like potassium channel (K (B)) they induce membrane depolarization and thus neurosecretion. |
1(0,0,0,1) | Details |