| Name | serine threonine kinase |
|---|---|
| Synonyms | PKU alpha; PKUa; PKUalpha; Protein kinase ubiquitous alpha; Serine/threonine kinase; Serine/threonine protein kinase tousled like 2; TLK 2; TLK2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18508033 | Chen YY, Chen G, Fan Z, Luo J, Ke ZJ: GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. Biochem Pharmacol. 2008 Jul 1;76(1):128-38. Epub 2008 Apr 29. Glycogen synthase kinase 3beta (GSK3beta), a multifunctional serine/threonine kinase, has been implicated in the pathogenesis of neurodegeneration. |
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| 20171192 | Um JW, Park HJ, Song J, Jeon I, Lee G, Lee PH, Chung KC: Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease. Biochem Biophys Res Commun. 2010 Mar 19;393(4):824-8. Epub 2010 Feb 18. We have recently shown that parkin (an E3 ubiquitin ligase) and PINK1 (a serine/threonine kinase) affect one other's stability, solubility, and tendency to form cytoprotective aggresomes (Um et al., 2009). Consistent with our previous findings from parkin knockout mice, rat models of PD -, rotenone-, or MG132-induced PD) were also associated with an increase in soluble and insoluble PINK1 levels as well as enhanced formation of parkin aggregates. |
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| 18257932 | Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z: Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener. 2008 Feb 8;3:3. However, dLRRK mutant flies were selectively sensitive to peroxide induced stress but not to paraquat, rotenone and beta-mercaptoethanol induced stresses. LRRK2 encodes a large putative serine/threonine kinase with GTPase activity. |
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| 15026413 | Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E: Beta-synuclein regulates Akt activity in neuronal cells. J Biol Chem. 2004 May 28;279(22):23622-9. Epub 2004 Mar 16. The main objective of the present study was to investigate the potential involvement of the serine threonine kinase Akt (also known as protein kinase B) signaling pathway in the mechanisms of beta-synuclein neuroprotection. Beta-synuclein transfection resulted in increased Akt activity and conferred protection from the effects of rotenone. |
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| 11368352 | Salsman S, Felts N, Pye QN, Floyd RA, Hensley K: Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN. Arch Biochem Biophys. 2001 Feb 15;386(2):275-80. Treatment with rotenone or antimycin A also resulted in increased wortmannin-sensitive Akt phosphorylation, probably by increasing intracellular H2O2 generation by blocking mitochondrial electron transport. |
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