Protein Information

Name glucagon
Synonyms GCG; GLP 1; GLP1; GLP 2; GLP2; GRPP; Glicentin related polypeptide; Glucagon…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
210759 Halestrap AP: Stimulation of the respiratory chain of rat liver mitochondria between cytochrome c1 and cytochrome c by glucagon treatment of rats. Biochem J. 1978 Jun 15;172(3):399-405.

Measurement of the cytochrome spectra under uncoupled conditions in the presence of succinate and rotenone demonstrates a crossover between cytochromes c and c (1) when control mitochondria are compared with those from glucagon-treated rats, cytochrome c being more oxidized and cytochrome c (1) more reduced in control mitochondria.
37(0,1,1,7) Details
240844 Yamazaki RK: Glucagon stimulation of mitochondrial respiration. J Biol Chem. 1975 Oct 10;250(19):7924-30.

5(0,0,0,5) Details
1575688 Jois M, Ewart HS, Brosnan JT: Regulation of glycine catabolism in rat liver mitochondria. . Biochem J. 1992 Apr 15;283 ( Pt 2):435-9.

Mitochondria isolated from rats previously injected with glucagon showed elevated rates of degradation of glycine even in the presence of rotenone, provided that regeneration of NAD+ was affected by providing acetoacetate. 4.
84(1,1,1,4) Details
708783 Joseph SK, McGivan JD: The effect of ammonium chloride and glucagon on the metabolism of glutamine in isolated liver cells from starved rats. Biochim Biophys Acta. 1978 Sep 21;543(1):16-28.

The effective activation of glutamine hydrolysis by ammonimum chloride in intact mitochondria was partially inhibited by rotenone and was abolished by uncoupling agents. 4.
6(0,0,0,6) Details
6200477 Handlogten ME, Kilberg MS: Induction and decay of amino acid transport in the liver. J Biol Chem. 1984 Mar 25;259(6):3519-25.

Turnover of transport activity in isolated hepatocytes after stimulation by diabetes or glucagon..
The decay was blocked by either actinomycin or cycloheximide, but was unaffected by leupeptin, methylamine, chloroquine, dinitrophenol, rotenone, or tunicamycin.
4(0,0,0,4) Details
6204980 Wingrove DE, Amatruda JM, Gunter TE: Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria. J Biol Chem. 1984 Aug 10;259(15):9390-4.

In both cases a tetraphenyl phosphonium electrode is used to follow membrane potential, and membrane potential is varied using either malonate or butylmalonate in the presence of rotenone.
4(0,0,0,4) Details
6136297 Hamman HC, Haynes RC Jr: Hormonal regulation of mitochondrial function. Biochim Biophys Acta. 1983 Aug 31;724(2):241-50.

Description of a system capable of mimicking several effects of glucagon..
Mitochondrial respiration is essential for the development of the activated state as the stimulation is blocked by increasing concentrations of rotenone in the incubation.
2(0,0,0,2) Details
7599232 Hoek JB, Farber JL, Thomas AP, Wang X: Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition. Biochim Biophys Acta. 1995 May 24;1271(1):93-102.

Hepatocytes were incubated with vasopressin, glucagon, or with thapsigargin (an inhibitor of the endoplasmic reticulum Ca2+ pump) prior to permeabilization with digitonin.
Mitochondrial Ca2+ accumulation was determined by following the ionomycin-induced Ca2+ release in permeabilized cells and mitochondrial swelling was studied by following cyclosporin A-sensitive light scattering changes induced by phenyl-arsenoxide and rotenone.
2(0,0,0,2) Details
140067 Yamazaki RK, Sax RD, Hauser MA: Glucagon stimulation of mitochondrial ATPase and potassium ion transport. FEBS Lett. 1977 Mar 15;75(1):295-9.

1(0,0,0,1) Details
6288019 Halestrap AP: The pathway of electron flow through ubiquinol:cytochrome c oxidoreductase in the respiratory chain. Biochem J. 1982 Apr 15;204(1):49-59.

Sites for the locus of action of glucagon and the protonmotive force on electron flow are suggested.
Colletotrichin inhibition of the ADP-stimulated oxidation of glutamate + malate was enhanced by succinate addition and declined again with rotenone addition.
1(0,0,0,1) Details
499518 Titheradge MA, Haynes RC Jr: Glucagon treatment stimulates the oxidation of durohydroquinone by rat liver mitochondria. FEBS Lett. 1979 Oct 15;106(2):330-4.

1(0,0,0,1) Details
8518295 Rao VV, Tsai MJ, Pan X, Chang YF: L-pipecolic acid oxidation in rat: subcellular localization and developmental study. Biochim Biophys Acta. 1993 Jun 24;1164(1):29-35.

Both rotenone and antimycin A completely inhibited the enzyme activity in mitochondria but not in peroxisomes.
The enzyme was shown to be inducible in mitochondria and peroxisomes of rat liver and brain tissues by glucagon and di-(2-ethylhexyl) phthalate, respectively.
1(0,0,0,1) Details
7056751 Reinhart PH, Taylor WM, Bygrave FL: Studies on alpha-adrenergic-induced respiration and glycogenolysis in perfused rat liver. J Biol Chem. 1982 Feb 25;257(4):1906-12.


The mitochondrial respiratory chain blockers antimycin A and rotenone, inhibited the alpha-agonist-induced oxygen uptake and glycogenolytic responses at inhibitor concentrations similar to those required to block uncoupler-stimulated respiration in the intact perfused liver.
0(0,0,0,0) Details