Protein Information

Name histone deacetylases (protein family or complex)
Synonyms Histone deacetylase; Histone deacetylases

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19626387 Monti B, Gatta V, Piretti F, Raffaelli SS, Virgili M, Contestabile A: Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein. Neurotox Res. 2010 Feb;17(2):130-41. Epub 2009 Jul 21.

Among its many cellular targets, VPA has been recently demonstrated to be an effective inhibitor of histone deacetylases.
2(0,0,0,2) Details
19835929 Wang Y, Wang X, Liu L, Wang X: HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells. Neurosci Lett. 2009 Dec 31;467(3):212-6. Epub 2009 Oct 14.

Histone deacetylase (HDAC) inhibitors have been shown associated with neurodegenerative diseases.
Pre-treatment with TSA resulted in exacerbated neurotoxic damage to dopaminergic neurons induced by 1-methyl-4-phenylpyridinium and rotenone.
1(0,0,0,1) Details