Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
15720824 Ichikawa H, Takagi T, Uchiyama K, Higashihara H, Katada K, Isozaki Y, Naito Y, Yoshida N, Yoshikawa T: Rotenone, a mitochondrial electron transport inhibitor, ameliorates ischemia-reperfusion-induced intestinal mucosal damage in rats. Redox Rep. 2004;9(6):313-6.

Co-administration with succinate (100 mg/kg), a substrate of the mitochondrial electron transport system, cancelled significant reduction of intraluminal hemoglobin and mucosal TBARS treated with rotenone alone.
82(1,1,1,2) Details
19479992 Richter F, Meurers BH, Zhu C, Medvedeva VP, Chesselet MF: Neurons express hemoglobin alpha- and beta-chains in rat and human brains. . J Comp Neurol. 2009 Aug 10;515(5):538-47.

Systemic administration of the mitochondrial inhibitor rotenone (2 mg/kg/d, 7d, s.c.) induced a marked decrease in Hba-a2 and Hbb but not neuroglobin or cytoglobin mRNA in transcriptome analyses of nigral dopaminergic neurons.
6(0,0,0,6) Details
3339013 Goretski J, Hollocher TC: Trapping of nitric oxide produced during denitrification by extracellular hemoglobin. J Biol Chem. 1988 Feb 15;263(5):2316-23.

The rate of HbNO formation was proportional to cell density, essentially independent of pH from 6.8 to 7.4, nearly zero order in [Hb] and, at least with Paracoccus denitrificans, strongly inhibited by rotenone and antimycin A.
2(0,0,0,2) Details
7595568 Erecinnska M, Nelson D, Vanderkooi JM: Effects of NO-generating compounds on synaptosomal energy metabolism. . J Neurochem. 1995 Dec;65(6):2699-705.

S-Nitrosocysteine, at 10 microM, inhibited by 80% respiration with glucose and succinate (plus rotenone) in intact synaptosomes and with ascorbate/cytochrome c in broken preparations.
Oxygenated hemoglobin reversed and/or prevented the inhibition, whereas glutathione (GSH) prolonged it.
1(0,0,0,1) Details
6794942 Bezkorovainy A, Topouzian N: The effect of metal chelators and other metabolic inhibitors on the growth of Bifidobacterium bifidus var. Clin Biochem. 1981 Jun;14(3):135-41.

The following had no effect on its growth: citrate, serum transferrin, serum albumin, colchicine, fluoro-acetate, malonate, and rotenone.
The following substances inhibited the growth: fluoride, azide, arsenite, 2, 4-dinitrophenol, hemin, hemoglobin, lactoferrin, alpha, alpha'-bipyridyl, and 8-hydroxyquinoline.
1(0,0,0,1) Details
15650392 Bundy RE, Hoare GS, Kite A, Beach J, Yacoub M, Marczin N: Redox regulation of p38 MAPK activation and expression of ICAM-1 and heme oxygenase-1 in human alveolar epithelial (A549) cells. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):14-24.


The mitochondrial complex I and III inhibitors, rotenone and antimycin A, and allopurinol partially inhibited H2O2- but not TNFalpha-induced p38 activation.
0(0,0,0,0) Details