Protein Information

Name citrate lyase (protein family or complex)
Synonyms Citrate lyase; Citrate lyases

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
1734891 Atlante A, Passarella S, Quagliariello E: Pyruvate/malate antiporter in rat liver mitochondria. . Biochem Biophys Res Commun. 1992 Jan 31;182(2):931-8.


To gain some insight into the process by which both acetylCoA and NADPH, needed for fatty acid synthesis, are obtained, in the cytosol, from the effluxed intramitochondrial citrate, via citrate lyase and malate dehydrogenase plus malic enzyme respectively, the capability of externally added pyruvate to cause efflux of malate from rat liver mitochondria was tested.
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4005310 Sanchez-Jimenez F, Martinez P, Nunez de Castro I, Olavarria JS: The function of redox shuttles during aerobic glycolysis in two strains of Ehrlich ascites tumor cells. Biochimie. 1985 Feb;67(2):259-64.

The glycerophosphate shuttle can be ruled out because of the lack of relevant enzymatic activities, and the failure of glucose to increase rotenone-inhibited respiration.
Estimation of citrate synthase and ATP citrate lyase, in addition to the observed high activity of malate dehydrogenase, suggests a malate-citrate shuttle.
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