Protein Information

Name Nicotinamide adenine dinucleotide phosphate oxidase
Synonyms DUOX; DUOX 1; DUOX1; Dual oxidase 1; Dual oxidase 1 precursor; Flavoprotein NADPH oxidase; LNOX 1; LNOX1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16647052 Muzaffar S, Shukla N, Angelini GD, Jeremy JY: Superoxide auto-augments superoxide formation and upregulates gp91 (phox) expression in porcine pulmonary artery endothelial cells: inhibition by iloprost. Eur J Pharmacol. 2006 May 24;538(1-3):108-14. Epub 2006 Mar 28.

Rotenone and allopurinol were without effect.
Central to the aetiology of Acute Respiratory Distress Syndrome (ARDS) is superoxide, the principal source of which is nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase).
1(0,0,0,1) Details
18854758 Nozoe M, Hirooka Y, Koga Y, Araki S, Konno S, Kishi T, Ide T, Sunagawa K: Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla. J Hypertens. 2008 Nov;26(11):2176-84.

Nicotinamide adenine dinucleotide phosphate oxidase is a major source of ROS in the central nervous system, which acts as a key mediator (mediators) of angiotensin II (AngII).
Overexpression of Mn-SOD and rotenone, a mitochondrial respiratory complex I inhibitor, suppressed AngII-induced ROS production.
1(0,0,0,1) Details