| Name | GADD153 |
|---|---|
| Synonyms | C/EBP homologous protein; CEBPZ; CHOP; CHOP/FUS fusion gene; CHOP10; DDIT 3; DDIT3; DNA damage inducible transcript 3… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12111836 | Conn KJ, Gao WW, Ullman MD, McKeon-O'Malley C, Eisenhauer PB, Fine RE, Wells JM: Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells. J Neurosci Res. 2002 Jun 15;68(6):755-60. Comparison of GADD153 expression among cultures treated with other toxins whose primary mode of action is either via mitochondrial impairment (rotenone) or via oxidative stress or peroxide) showed that GADD153 was uniquely up-regulated by MPP (+). |
10(0,0,1,5) | Details |
| 14649730 | Conn KJ, Ullman MD, Larned MJ, Eisenhauer PB, Fine RE, Wells JM: cDNA microarray analysis of changes in gene expression associated with MPP+ toxicity in SH-SY5Y cells. Neurochem Res. 2003 Dec;28(12):1873-81. RT-PCR analysis of a subset of genes showed that c-Myc and RNA-binding protein 3 (RMB3) expression decreased by approximately 50% after 72 h of exposure to MPP+ (1 mM) but did not change after 72 h of exposure to (25 microM), rotenone (50 nM), and peroxide (600 microM). Exposure of (RA)-differentiated SH-SY5Y cells to MPP+ (1 mM, 72 h) also resulted in a decrease in RMB3 expression and an increase in GADD153 expression. |
1(0,0,0,1) | Details |