Protein Information

Name IDDM
Synonyms IDDM; IDDM 1; IDDM1; IDDM 2; IDDM2; ILPR; insulin dependent diabetes mellitus 2; insulin dependent diabetes mellitus 2s

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
10433094 Myers MA, Georgiou HM, Byron S, Esposti MD: Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells. Autoimmunity. 1999;30(1):43-51.


It has been hypothesised that mitochondrial dysfunction in pancreatic beta cells could produce hyper-expression of glutamic acid decarboxylase (GAD), a major autoantigen in insulin-dependent diabetes mellitus (IDDM) (Degli Esposti, M. and Mackay, I.R.
2(0,0,0,2) Details