Protein Information

Name APAF 1
Synonyms APAF1; Apaf 1; Apaf1; Apoptotic protease activating factor; Apoptotic protease activating factor1; Apoptotic protease activating factor 1; CED4; apoptotic peptidase activating factor…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16313906 Pan T, Li X, Xie W, Jankovic J, Le W: Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells. FEBS Lett. 2005 Dec 19;579(30):6716-20. Epub 2005 Nov 21.

We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1.
81(1,1,1,1) Details
16207793 Potokar M, Kreft M, Chowdhury HH, Vardjan N, Zorec R: Subcellular localization of Apaf-1 in apoptotic rat pituitary cells. Am J Physiol Cell Physiol. 2006 Mar;290(3):C672-7. Epub 2005 Oct 5.

We show herein that 2 h after triggering apoptosis with rotenone, Apaf-1 redistributed to the proximity of mitochondria.
10(0,0,1,5) Details
16184340 Ruggieri M, Avolio C, Scacco S, Pica C, Lia A, Zimatore GB, Papa S, Livrea P, Trojano M: Glatiramer acetate induces pro-apoptotic mechanisms involving Bcl-2, Bax and Cyt-c in peripheral lymphocytes from multiple sclerosis patients. J Neurol. 2006 Feb;253(2):231-6. Epub 2005 Sep 30.


We analyzed the mitochondria membrane pro- (Bax) and anti-apoptotic (Bcl- 2) and cytosolic pro-apoptotic (Cyt-c, APAF-1) proteins expression in peripheral lymphocytes from relapsing-remitting (RR) MS patients during GA treatment.
3(0,0,0,3) Details