Protein Information

Name per 1
Synonyms Circadian pacemaker protein Rigui; PER; PER 1; PER1; Period circadian protein 1; RIGUI; hPER; period (Drosophila) homolog 1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
7402127 Romanova AK, Emnova EE: [Functional characteristics of the membrane preparations from the cells of the thermophilic hydrogen bacterium. Mikrobiologiia. 1980 May-Jun;49(3):493-6.

The membrane preparations, after exhaustion of endogenous substrates in them, oxidized NADH and succinate at rates of 4.00 and 0.83 mumole/min per 1 mg of membrane protein, respectively.
The oxidation of NADH was inhibited by rotenone and cyanide, while the oxidation of succinate, only by cyanide.
1(0,0,0,1) Details
10371157 Galkin AS, Grivennikova VG, Vinogradov AD: --> H+/2e- stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. FEBS Lett. 1999 May 21;451(2):157-61.

Quantitation of the initial rates of NADH oxidation and external H+ decrease resulted in a stoichiometric ratio of 4 H+ vectorially translocated per 1 NADH oxidized at pH 8.0.
Rotenone, piericidin and thermal deactivation of complex I completely prevented NADH-induced proton translocation in the NADH-endogenous ubiquinone reductase reaction.
1(0,0,0,1) Details
6344368 Poliakova IA, Zorov DB, Leikina MI: [Polarographic study of cell respiration in a tissue culture] . Tsitologiia. 1983 Feb;25(2):162-7.

Oxygen consumption is linear in time at the O2 concentration within the range from 480 to 200 nanoatoms per 1 ml of medium.
The respiration rate is found to be enhanced by uncoupler and suppressed by the inhibitors of the electron flow chain (NaCN, antimycin A, amytal, rotenone) and mitochondrial ATPase (oligomycin and diciclohexylcarbodiimide).
1(0,0,0,1) Details