Protein Information

Name CTGF
Synonyms CCN 2; CCN2; CTGF; Connective tissue growth factor; Connective tissue growth factor precursor; FISP 12 protein; HCS24; Hypertrophic chondrocyte specific protein 24…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16344601 French SW: The pathogenesis and significance of the urinary alcohol cycle in rats fed ethanol intragastrically. Alcohol Clin Exp Res. 2005 Nov;29(11 Suppl):158S-161S.

When complex I (NADH dehydrogenase) of the mitochondrial electron transport chain is inhibited by feeding rotenone, the cycle is totally eliminated and blood alcohol levels remain constant at 200 mg/%.
Genes such as c-fos and CTGF are increased in expression.
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11710721 Sambo P, Baroni SS, Luchetti M, Paroncini P, Dusi S, Orlandini G, Gabrielli A: Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum. 2001 Nov;44(11):2653-64.


This suppression was not seen with rotenone, a mitochondrial oxidase inhibitor, or allopurinol, a xanthine oxidase inhibitor.
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