| Name | LRRK2 |
|---|---|
| Synonyms | Dardarin; LRRK 2; LRRK2; Leucine rich repeat kinase 2; Leucine rich repeat serine/threonine protein kinase 2; PARK 8; PARK8; Parkinson disease (autosomal dominant) 8… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18322385 | Wolozin B, Saha S, Guillily M, Ferree A, Riley M: Investigating convergent actions of genes linked to familial Parkinson's disease. Neurodegener Dis. 2008;5(3-4):182-5. Epub 2008 Mar 6. OBJECTIVES: To investigate how expressing wild-type or G2019S LRRK2 modifies cellular responses to rotenone, a mitochondrial toxin. |
95(1,1,3,5) | Details |
| 19741132 | Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL: Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J Neurosci. 2009 Sep 9;29(36):11257-62. Furthermore, LRRK2 mutant flies also display reduced lifespan and increased sensitivity to rotenone, a mitochondrial complex I inhibitor. |
93(1,1,2,8) | Details |
| 19625511 | Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B: LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci. 2009 Jul 22;29(29):9210-8. Expressing human LRRK2 increased nematode survival in response to rotenone or paraquat, which are agents that cause mitochondrial dysfunction. |
14(0,0,1,9) | Details |
| 19692353 | Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS: Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet. 2009 Nov 15;18(22):4390-404. Epub 2009 Aug 19. However, these flies were more sensitive to rotenone. |
6(0,0,0,6) | Details |
| 18257932 | Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z: Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener. 2008 Feb 8;3:3. However, dLRRK mutant flies were selectively sensitive to peroxide induced stress but not to paraquat, rotenone and beta-mercaptoethanol induced stresses. |
6(0,0,0,6) | Details |
| 20030238 | Takahashi R, Kawamata J, Takeuchi H: [Pathogenesis of sporadic Parkinson's disease: contribution of genetic and environmental risk factors]. Rinsho Shinkeigaku. 2009 Nov;49(11):885-7. GBA and LRRK, the genes responsible for Gaucher disease and PARK8, respetively, are also likely to affect the development of PD. Mitochondrial complex I inhibitors, such as MPTP and rotenone, induce selective dopaminergic neuronal death, suggesting that chemicals may constitute risk factors of sporadic PD. |
1(0,0,0,1) | Details |