| Name | JNK1 |
|---|---|
| Synonyms | Mitogen activated protein kinase 8; JNK 1; JNK 46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18218673 | Jin S, Ray RM, Johnson LR: TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive species. Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G928-37. Epub 2008 Jan 24. Previously we have shown that both Rac1 and c-Jun NH (2)-terminal kinase (JNK1/2) are key proapoptotic molecules in tumor necrosis factor (TNF)-alpha/cycloheximide (CHX)-induced apoptosis in intestinal epithelial cells, whereas the role of reactive species (ROS) in apoptosis is unclear. The antioxidant, (NAC), or rotenone (Rot), the mitochondrial electron transport chain inhibitor, attenuated mitochondrial ROS production and apoptosis. |
3(0,0,0,3) | Details |
| 15328001 | Alba G, El Bekay R, Alvarez-Maqueda M, Chacon P, Vega A, Monteseirin J, Santa Maria C, Pintado E, Bedoya FJ, Bartrons R, Sobrino F: Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. FEBS Lett. 2004 Aug 27;573(1-3):219-25. Furthermore, also strongly reduced PMA-dependent H2O2 release, and induced the phosphorylation of c-jun N-terminal kinase 1 (p46), p38 mitogen-activated protein kinase and extracellular signal-regulated kinase. |
1(0,0,0,1) | Details |
| 10780954 | Lin Z, Weinberg JM, Malhotra R, Merritt SE, Holzman LB, Brosius FC 3rd: GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation. . Am J Physiol Endocrinol Metab. 2000 May;278(5):E958-66. These findings show that GLUT-1 overexpression prevents hypoxia-induced apoptosis possibly via inhibition of stress-activated protein kinase pathway activation. Similar protection against cell death and apoptosis was seen in GLUT-1-overexpressing cells treated for 6 h with the electron transport inhibitor rotenone. |
1(0,0,0,1) | Details |
| 12730670 | Djavaheri-Mergny M, Wietzerbin J, Besancon F: induces apoptosis in Ewing sarcoma cells through mitochondrial peroxide production. Oncogene. 2003 May 1;22(17):2558-67. Rotenone, an inhibitor of the mitochondrial respiratory chain, abolished both apoptosis and H (2) O (2) production, thereby identifying mitochondria as the source of H (2) O (2). |
0(0,0,0,0) | Details |