| Name | cyclophilin D |
|---|---|
| Synonyms | 40 kDa peptidyl prolyl cis trans isomerase; PPIase; Rotamase; Peptidyl prolyl cis trans isomerase; CYP 40; CYP40; CYPD; Cyclophilin 40… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18614807 | He Y, Ge J, Tombran-Tink J: Mitochondrial defects and dysfunction in regulation in glaucomatous trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4912-22. Epub 2008 Jul 9. METHODS: Primary cultures of TM cells from POAG (GTM) and age-matched, nondiseased (NTM) eyes, obtained from postmortem donors eyes by standard surgical trabeculectomy, were treated with the following regulators: the mitochondrial respiratory chain I inhibitor rotenone (ROT); the mitochondrial permeability transition pore (MPTP) inhibitors cyclosporine (Cys) and aristolochic acid (ArA); the Ca (2+) chelators BAPTA/AM or EDTA; the mitochondrial Ca (2+) uniporter inhibitor ruthenium red (RR); the Ca (2+)/Na (+) exchanger inhibitor trifluoperazine; and the inositol 1,4,5- receptor type 3 (IP3R) inhibitors 2-aminoethoxydiphenyl borane (2-APB) and xestospongin C (Xe-C). The expression of cyclophilin D, a protein that induces MPTP opening was also measured. |
3(0,0,0,3) | Details |
| 12065751 | Waldmeier PC, Feldtrauer JJ, Qian T, Lemasters JJ: Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol. 2002 Jul;62(1):22-9. Cyclosporin A (CsA) shows cytoprotective properties in many cellular and in vivo models that may depend on interference of the interaction of cyclophilin A with calcineurin or of cyclophilin D with the mitochondrial permeability transition (PT) pore. Using two newly developed microtiter plate assays, one measuring mitochondrial swelling from absorbance and the other measuring mitochondrial membrane potential from changes in safranin fluorescence, we show that NIM811 blocks the MPT induced by and inorganic alone or in combination with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, the complex I inhibitor rotenone, and the prooxidant t-butylhydroperoxide. |
1(0,0,0,1) | Details |
| 9575230 | Eriksson O, Fontaine E, Bernardi P: Chemical modification of arginines by and phenylglyoxal causes closure of the mitochondrial permeability transition pore. J Biol Chem. 1998 May 15;273(20):12669-74. At concentrations that were fully effective at inhibiting the permeability transition, these reagents (i) had no effect on the isomerase activity of cyclophilin D and (ii) did not affect the rate of ATP translocation and hydrolysis, as measured by the production of a membrane potential upon ATP addition in the presence of rotenone. |
0(0,0,0,0) | Details |