| Name | Lipoxygenase (protein family or complex) |
|---|---|
| Synonyms | arachidonate lipoxygenase; arachidonate lipoxygenases; lipoxygenase; lipoxygenases |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11121805 | Hsieh CC, Yen MH, Yen CH, Lau YT: Oxidized low density lipoprotein induces apoptosis via generation of reactive species in vascular smooth muscle cells. Cardiovasc Res. 2001 Jan;49(1):135-45. Since oxLDL-induced ROS generation were inhibited by nordihydroguaiaretic acid and rotenone, lipoxygenase and mitochondrial pathways could be involved. |
32(0,1,1,2) | Details |
| 17881465 | Ding G, Zhang A, Huang S, Pan X, Zhen G, Chen R, Yang T: ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1889-97. Epub 2007 Sep 19. In contrast, inhibitors of other oxidant-producing enzymes, including the mitochondrial complex I inhibitor rotenone, the xanthine oxidase inhibitor allopurinol, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguiaretic acid, the cytochrome P-450 oxygenase inhibitor ketoconazole, and the synthase inhibitor N (G)-nitro- methyl ester, were without effect. |
31(0,1,1,1) | Details |
| 19781192 | Chen Y, Zhang AH, Huang SM, Ding GX, Zhang WZ, Bao HY, Wu HM, Chen RH: oxidase-derived reactive species involved in angiotensin II-induced monocyte chemoattractant protein-1 expression in mesangial cells]. Zhonghua Bing Li Xue Za Zhi. 2009 Jul;38(7):456-61. In contrast, inhibitors of other oxidant-producing enzymes, including the mitochondrial complex Iinhibitor rotenone, the xanthine oxidase inhibitor allopurinol, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguiaretic acid, the cytochrome P450 oxygenase inhibitor ketoconazole and the synthase inhibitor G-nitro- methyl ester were without an effect. |
31(0,1,1,1) | Details |
| 6269601 | Schewe T, Albracht SP, Ludwig P: On the site of action of the inhibition of the mitochondrial respiratory chain by lipoxygenase. Biochim Biophys Acta. 1981 Jul;636(2):210-7. The Fe-S clusters of the mitochondrial outer membrane are destroyed by lipoxygenase treatment, without any effect on the rotenone-insensitive cytochrome c oxidoreductase activity. |
9(0,0,1,4) | Details |
| 7646435 | O'Donnell VB, Spycher S, Azzi A: Involvement of oxidants and oxidant-generating enzyme (s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. Biochem J. 1995 Aug 15;310 ( Pt 1):133-41. Finally, we suggest a central role for lipoxygenase in TNF alpha-mediated lysis. We also demonstrated no role for mitochondrial-derived radicals/respiratory chain in the lytic pathway using specific inhibitors/uncouplers (rotenone, KCN, carboxin, fluoroacetate, antimycin, carbonyl p-trifluoromethoxyphenylhydrazone) and chloramphenicol-derived respiration-deficient cells. |
3(0,0,0,3) | Details |
| 7810685 | Mohazzab KM, Wolin MS: Sites of production detected by lucigenin in calf pulmonary artery smooth muscle. Am J Physiol. 1994 Dec;267(6 Pt 1):L815-22. Quantitation of certain other potential sources of O2-. (under optimized conditions), including xanthine oxidase (0.1 mM mitochondria (5 mM + 30 microM antimycin), cyclooxygenase/lipoxygenase (1 microM + 0.1 mM or autooxidation (0.1 mg/ml superoxide dismutase), resulted in the detection of minimal amounts (< 3% of of chemiluminescence. These observations were confirmed by examination of chemiluminescence produced by subcellular fractions, where the major activity detected was an oxidoreductase, which fractionated in a manner closely matching the activity of the microsomal marker enzyme rotenone-insensitive -cytochrome c reductase. |
1(0,0,0,1) | Details |
| 16701962 | Wangensteen H, Miron A, Alamgir M, Rajia S, Samuelsen AB, Malterud KE: Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus. Fitoterapia. 2006 Jun;77(4):290-5. Epub 2006 May 15. |
1(0,0,0,1) | Details |
| 8836123 | O'Donnell VB, Azzi A: High rates of extracellular generation by cultured human fibroblasts: involvement of a lipid-metabolizing enzyme. Biochem J. 1996 Sep 15;318 ( Pt 3):805-12. Inhibitor studies showed that there was no involvement of oxidase (diphenylene iodonium, diphenyl iodonium), prostaglandin H synthase (indomethacin), xanthine oxidase (allopurinol), cytochrome P-450 or mitochondrial respiration (rotenone, antimycin A). Several features suggest involvement of an enzyme related to 15-lipoxygenase, and, in support of this, we show generation and oxidation by recombinant rabbit reticulocyte 15-lipoxygenase. |
1(0,0,0,1) | Details |
| 9258337 | Tang DG, Honn KV: Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival. J Cell Physiol. 1997 Aug;172(2):155-70. W256 cell apoptosis induced by NDGA could also be effectively inhibited by GSH-elevating or thiol agents as well as by lipid peroxidation inhibitors and an inhibitor of mitochondria respiratory chain rotenone. Arachidonate lipoxygenases (LOX) and their products play an important role in mediating growth factor-supported tumor cell proliferation and growth. |
1(0,0,0,1) | Details |
| 16666054 | Day DA, Moore AL, Dry IB, Wiskich JT, Azcon-Bieto J: Regulation of Nonphosphorylating Electron Transport Pathways in Soybean Cotyledon Mitochondria and Its Implications for Fat Metabolism. Plant Physiol. 1988 Apr;86(4):1199-1204. Despite substantial rotenone-resistant O (2) uptake with NAD-linked substrates, respiratory control was observed in the presence of antimycin, indicating restriction of electron flow through complex I. |
0(0,0,0,0) | Details |
| 16531806 | Lijnen P, Papparella I, Petrov V, Semplicini A, Fagard R: Angiotensin II-stimulated collagen production in cardiac fibroblasts is mediated by reactive species. J Hypertens. 2006 Apr;24(4):757-66. Rotenone, allopurinol, indomethacin, nordihydroguiaretic acid, ketoconazole and nitro- (inhibitors of mitochondrial NAD (P) H oxidase, xanthine oxidase, cyclooxygenase, lipoxygenase, cytochrome P450 oxygenase and synthase, respectively) did not affect the angiotensin II-induced collagen production. |
0(0,0,0,0) | Details |
| 15986371 | Remans PH, van Oosterhout M, Smeets TJ, Sanders M, Frederiks WM, Reedquist KA, Tak PP, Breedveld FC, van Laar JM: Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2005 Jul;52(7):2003-9. Superoxide dismutase, which uses as a substrate to form H2O2, diphenyleneiodonium (an inhibitor of oxidase), N (G)-monomethyl- (an inhibitor of synthesis), nordihydroguaiaretic acid (an inhibitor of lipoxygenase), and rotenone (an inhibitor of mitochondrial ROS production) failed to suppress ROS production. |
0(0,0,0,0) | Details |
| 16895947 | Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA: Cis-unsaturated fatty acids stimulate reactive species generation and lipid peroxidation in human spermatozoa. J Clin Endocrinol Metab. 2006 Oct;91(10):4154-63. Epub 2006 Aug 8. This effect could not be blocked with inhibitors of the cyclooxygenase or lipoxygenase pathways of AA metabolism, rotenone, protein kinase C antagonists, or known inhibitors of plasma membrane redox systems. |
0(0,0,0,0) | Details |
| 8648915 | Zager RA: Mitochondrial free radical production induces lipid peroxidation during myohemoglobinuria. Kidney Int. 1996 Mar;49(3):741-51. Site 2 (antimycin A) or site 3 hypoxia) mitochondrial respiratory chain inhibition completely blocked lipid peroxidation, whereas site 1 inhibition (rotenone) doubled its extent (presumably by shunting through NADH dehydrogenase, a free radical generating system). |
0(0,0,0,0) | Details |