Protein Information

Name gamma glutamylcysteine synthetase
Synonyms GCLM; GCS light chain; GLCLR; Gamma ECS; Gamma glutamylcysteine synthetase; Gamma glutamylcysteine synthetase regulatory subunit; Glutamate cysteine ligase modifier subunit; Glutamate cysteine ligase regulatory subunit…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
9374527 Morales A, Garcia-Ruiz C, Miranda M, Mari M, Colell A, Ardite E, Fernandez-Checa JC: Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase. J Biol Chem. 1997 Nov 28;272(48):30371-9.

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1540380 Kinnula VL, Whorton AR, Chang LY, Crapo JD: Regulation of hydrogen peroxide generation in cultured endothelial cells. . Am J Respir Cell Mol Biol. 1992 Feb;6(2):175-82.


Furthermore, inhibition of the mitochondrial respiratory chain (rotenone, antimycin A) or microsomal cytochrome P-450 (8-methoxypsoralen) did not change extracellular H2O2 release or intracellular H2O2 production (at peroxisomes) by endothelial cells or cells in which glutathione reductase was inactivated.
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