| Name | PC 3 |
|---|---|
| Synonyms | PC 3; secreted microprotein PC 3; secreted microprotein PC 3s |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15561720 | Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, Buettner GR, Venkataraman S, Mackey MA, Flanagan SW, Oberley LW, Spitz DR: Mitochondrial O2*- and H2O2 mediate deprivation-induced stress in human cancer cells. J Biol Chem. 2005 Feb 11;280(6):4254-63. Epub 2004 Nov 23. The hypothesis that deprivation-induced cytotoxicity in transformed human cells is mediated by mitochondrial O2*- and H2O2 was first tested by exposing -deprived SV40-transformed human fibroblasts (GM00637G) to electron transport chain blockers (ETCBs) known to increase mitochondrial O2*- and H2O2 production (antimycin A (AntA), myxothiazol (Myx), or rotenone (Rot)). deprivation in the presence of AntA also significantly enhanced cytotoxicity and parameters indicative of oxidative stress in several different human cancer cell lines (PC-3, DU145, MDA-MB231, and HT-29). |
3(0,0,0,3) | Details |
| 12821677 | Ling YH, Liebes L, Zou Y, Perez-Soler R: Reactive species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem. 2003 Sep 5;278(36):33714-23. Epub 2003 Jun 23. In PC-3 prostate carcinoma cells (with overexpression of Bcl-2), a reduction of bortezomib-induced ROS generation, Delta psi m increase was correlated with cellular resistance to bortezomib and the attenuation of drug-induced apoptosis. Co-incubation with rotenone and antimycin A, inhibitors of mitochondrial electron transport chain complexes I and III, or with cyclosporine A, an inhibitor of mitochondrial permeability transition pore, resulted in inhibition of bortezomib-induced ROS generation, increase in Delta psi m, and cytochrome c release. |
1(0,0,0,1) | Details |
| 16781454 | Kachadourian R, Day BJ: -induced depletion: potential implications for cancer treatment. Free Radic Biol Med. 2006 Jul 1;41(1):65-76. Epub 2006 Mar 31. The ability of a number of flavonoids to induce (GSH) depletion was measured in lung (A549), myeloid (HL-60), and prostate (PC-3) human tumor cells. Prototypic flavonoids (2',5'-DHC and chrysin) were subsequently tested for their abilities to potentiate the toxicities of prooxidants (etoposide, rotenone, and |
3(0,0,0,3) | Details |
| 15764812 | Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz A: -induced cell death in human prostate cancer cells is initiated by reactive species. J Biol Chem. 2005 May 20;280(20):19911-24. Epub 2005 Mar 11. Using PC-3 and DU145 human prostate cancer cells as a model, we now demonstrate, for the first time, that the initial signal for SFN-induced apoptosis is derived from reactive oxygen species (ROS). The SFN-induced ROS generation was significantly attenuated on pretreatment with mitochondrial respiratory chain complex I inhibitors, including diphenyleneiodonium and rotenone. |
2(0,0,0,2) | Details |
| 17565155 | Oh SH, Woo JK, Yazici YD, Myers JN, Kim WY, Jin Q, Hong SS, Park HJ, Suh YG, Kim KW, Hong WK, Lee HY: Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst. 2007 Jun 20;99(12):949-61. Epub 2007 Jun 12. METHOD: Human xenograft tumors were generated in mice from H1299 (n = 6 per group) and A549 (n = 4 per group) non-small-cell lung cancer cells, UMSCC38 (n = 5 per group) head and neck cancer cells, MKN45 (n = 5 per group) stomach cancer cells, and PC-3 (n = 3 per group) prostate cancer cells. |
1(0,0,0,1) | Details |
| 9644064 | Oberlies NH, Rogers LL, Martin JM, McLaughlin JL: Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana. J Nat Prod. 1998 Jun 26;61(6):781-5. All have activity against six human tumor cell lines in culture and show selectivity for human prostate adenocarcinoma (PC-3) cells with 3 being nearly as potent as adriamycin. Also, when tested against yellow fever mosquito larva, 3 was more effective than rotenone, a natural botanical insecticide and positive control. |
1(0,0,0,1) | Details |
| 9322367 | Alali FQ, Zhang Y, Rogers L, McLaughlin JL: (2,4-cis and trans)-gigantecinone and 4-deoxygigantecin, bioactive nonadjacent bis-tetrahydrofuran annonaceous acetogenins, from Goniothalamus giganteus. J Nat Prod. 1997 Sep;60(9):929-33. Both 1 and 1b showed potent and selective cytotoxicities against the PC-3 human prostate adenocarcinoma cell line. Against yellow fever mosquito larvae, 1 and 2 were more potent than rotenone in pesticidal activity. |
1(0,0,0,1) | Details |