Protein Information

Name cyclin dependent kinase (protein family or complex)
Synonyms cyclin dependent kinase; cyclin dependent kinases

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17343987 Alvira D, Tajes M, Verdaguer E, de Arriba SG, Allgaier C, Matute C, Trullas R, Jimenez A, Pallas M, Camins A: Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons. Neuroscience. 2007 Apr 25;146(1):350-65. Epub 2007 Mar 7.

2(0,0,0,2) Details
16107721 Behrend L, Mohr A, Dick T, Zwacka RM: Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. Mol Cell Biol. 2005 Sep;25(17):7758-69.

In addition, depolarization of the mitochondrial membrane by mitochondrial inhibitors such as rotenone or antimycin A led colorectal cancer cells into p53-dependent senescence.
MnSOD overexpression causes up-regulation of p53 and its transcriptional target, the cyclin-dependent kinase inhibitor p21.
1(0,0,0,1) Details