| Name | phosphate carrier |
|---|---|
| Synonyms | Mitochondrial carrier; PTP; Mitochondrial phosphate carrier protein; OK/SW cl.48; PHC; Phosphate carrier; PiC; SLC25A3… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 444501 | Le Quoc K, Le Quoc D, Gaudemer Y: Influence of the energetic state of mitochondria on the inhibition of oxidative phosphorylation by N-ethylmaleimide. Biochim Biophys Acta. 1979 May 9;546(2):356-64. Using a reversible thiol reagent (mersalyl), in order to protect the phosphate carrier against irreversible action of N-ethylmaleimide, it was found that: (a) when mersalyl-pretreated mitochondria were in a 'non-energized' state, i.e. preincubated without a substrate and in the presence of rotenone, only a slight inhibition of oxidation coupled to ATP synthesis by N-ethylmaleimide was observed. (b) when mersalyl-pretreated mitochondria were in an 'energized' state, i.e. preincubated in the presence of an oxidizable substrate, N-ethylmaleimide strongly inhibited the coupled oxidation of 2. |
31(0,1,1,1) | Details |
| 35536 | Villalobo A, Lehninger AL: The stoichiometry of electron transport in Ehrlich ascites tumor mitochondria. J Biol Chem. 1979 Jun 10;254(11):4352-8. With as substrate and N-ethylmaleimide to prevent interfering H+ reuptake via the phosphate carrier, close to 8 H+ were ejected per atom reduced (H+/O ejection ratio = 8.0); with the NAD-linked substrates or + the H+/O ejection ratio was close to 12. |
1(0,0,0,1) | Details |
| 10727400 | Rossignol R, Letellier T, Malgat M, Rocher C, Mazat JP: Tissue variation in the control of oxidative phosphorylation: implication for mitochondrial diseases. Biochem J. 2000 Apr 1;347 Pt 1:45-53. The analysis of control coefficient distribution shows two tissue groups: (i) the muscle and the heart, controlled essentially at the level of the respiratory chain; and (ii) the liver, the kidney and the brain, controlled mainly at the phosphorylation level by ATP synthase and the phosphate carrier. |
1(0,0,0,1) | Details |