| Name | metalloproteinase |
|---|---|
| Synonyms | Leukolysin; MMP20; Matrix metalloproteinase 20; MMP25; MMP 25; MMP20A; MMPL 1; MMPL1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17395008 | Del Carlo M, Schwartz D, Erickson EA, Loeser RF: Endogenous production of reactive species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. Free Radic Biol Med. 2007 May 1;42(9):1350-8. Epub 2007 Jan 24. Preincubation of chondrocytes with rotenone, an inhibitor of the mitochondrial electron transport chain, or nordihydroguaiaretic acid (NDGA), a selective 5-lipoxygenase inhibitor, partially prevented FN-f-stimulated MMP-13 production and decreased MAP kinase and NF-kappaB phosphorylation. |
2(0,0,0,2) | Details |
| 20231142 | Villa-Abrille MC, Caldiz CI, Ennis IL, Nolly MB, Casarini MJ, Chiappe de Cingolani GE, Cingolani HE, Perez NG: The Anrep effect requires transactivation of the epidermal growth factor receptor. J Physiol. 2010 Mar 15. The SFR was 123+/-1% of rapid phase (n=6, P <0.05) and was blunted by preventing EGFR transactivation with the Src-kinase inhibitor (PP1, 99+/-2%, n=4), the matrix metalloproteinase inhibitor (MMPI, 8+/-4%, n=11), by EGFR blockade (AG1478, 98+/-2%, n=6) or the mitochondrial transition pore blocker (clyclosporine, 99+/-3%, n=6). EGF increased O2- production by 149+/-4% of control (n=9, P <0.05), effect canceled by inhibiting oxidase (apocynin, 110+/-6% n=7), mKATP channels (5-HD, 105+/-5%, n=8), respiratory chain (rotenone, 110+/-7%, n=7) or MPTP (Cyclosporine, 111+/-10%, n=6). |
1(0,0,0,1) | Details |