| 16749863 |
Souid AK, Penefsky HS, Sadowitz PD, Toms B: Enhanced cellular respiration in cells exposed to doxorubicin. . Mol Pharm. 2006 May-Jun;3(3):307-21.
To further define the effects of doxorubicin on cell metabolism, we measured cellular respiration, cellular ATP, DNA fragmentation, and cytochrome c leakage in Jurkat (supersensitive), human leukemia-60 (HL-60, sensitive), and HL-60/MX2 (resistant) cells following exposure to 1.0 microM doxorubicin for 30 min.
The conclusion that both of the latter processes were products of oxidations in the mitochondrial respiratory chain was supported by the further observation that rotenone and sodium cyanide inhibited oxygen consumption and substantially lowered ATP content in the treated and untreated cells. |
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