Protein Information

Name carnitine palmitoyltransferase I
Synonyms CPT I; CPT 1; CPT1; CPT1 L; CPT1A; CPTI L; Carnitine palmitoyltransferase 1A; Carnitine palmitoyltransferase I…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
8313432 McMillin JB, Taffet GE, Taegtmeyer H, Hudson EK, Tate CA: Mitochondrial metabolism and substrate competition in the aging Fischer rat heart. Cardiovasc Res. 1993 Dec;27(12):2222-8.

No significant changes in either glutamate or succinate (+rotenone) supported respiration were found in heart mitochondria isolated from old rats compared with mature animals.
A significant lowering of heart mitochondrial carnitine palmitoyltransferase I activity was also found in the old animals.
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1872864 Jakobs BS, Wanders RJ: Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts. Biochem Biophys Res Commun. 1991 Aug 15;178(3):842-7.


The oxidation of both fatty acids was found to be inhibited by rotenone plus antimycin and cyanide, respectively, although to a different extent.
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10421226 Zhou YP, Cockburn BN, Pugh W, Polonsky KS: Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism. Metabolism. 1999 Jul;48(7):857-64.


Insulin secretion at 2.8 mmol/L glucose was suppressed approximately 70% to 80% in islets from ZDF and ZF rats following exposure to diazoxide, a K+-adenosine triphosphate (K (ATP)) channel opener that inhibits membrane depolarization, or rotenone and oligomycin, agents that inhibit ATP production, or by incubation at 23 degrees C.
0(0,0,0,0) Details