Protein Information

Name Ciliary neurotrophic factor
Synonyms CNTF; Ciliary neurotrophic factor; HCNTF; Ciliary neurotrophic factors

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
15748169 Kaur N, Lu B, Monroe RK, Ward SM, Halvorsen SW: Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons. J Neurochem. 2005 Mar;92(6):1521-30.

Also, two other mediators of oxidative stress, nitric oxide and rotenone, inhibited CNTF signaling.
87(1,1,1,7) Details
19635391 Monroe RK, Halvorsen SW: Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption. Neurotoxicology. 2009 Jul;30(4):589-98. Epub 2009 Apr 1.

Exposure of BE (2)-C cells to the heavy metals CdCl (2) and HgCl (2) and to the mitochondrial complex I inhibitor rotenone inhibited interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduced Jak1 and Jak2 auto-phosphorylation and induced Jak tyrosine nitration.
81(1,1,1,1) Details