| Name | phospholipase C |
|---|---|
| Synonyms | PLC L; PLCE; PLC L (PLC epsilon); PLCL; PLCL 1; PLCL1; PLDL 1; PLDL1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 213108 | Feo F, Canuto RA, Garcea R, Brossa O: The role of lipid-protein interactions in -cytochrome c reductase (rotenone-insensitive) of rat liver mitochondria. Biochim Biophys Acta. 1978 Oct 11;504(1):1-14. The phospholipid depletion of rat liver mitochondria, induced by acetoneextraction or by digestion with phospholipase A2 or phospholipase C, greatly inhibited the activity of -cytochrome c reductase (rotenone-insensitive). |
81(1,1,1,1) | Details |
| 1123334 | McMillin Wood J: palymityltransferase in neonatal and adult heart and liver mitochondria. J Biol Chem. 1975 Apr 25;250(8):3062-6. Effect of phospholipase C treatment.. |
2(0,0,0,2) | Details |
| 17634444 | Li Y, Chandrakanthan V, Day ML, O'Neill C: Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. Biol Reprod. 2007 Nov;77(5):813-21. Epub 2007 Jul 18. PIP3 acts as a docking site on membranes for proteins that contain pleckstrin homology domains, such as the thymoma viral proto-oncogene protein (AKT) and phospholipase C gamma. |
2(0,0,0,2) | Details |
| 19243382 | Exintaris B, Nguyen DT, Lam M, Lang RJ: Inositol trisphosphate-dependent Ca stores and mitochondria modulate slow wave activity arising from the smooth muscle cells of the guinea pig prostate gland. Br J Pharmacol. 2009 Apr;156(7):1098-106. Epub 2009 Feb 25. Blockade of inositol trisphosphate receptor (IP (3) R)-mediated Ca (2+) release with 2-aminoethoxy-diphenylborate (60 micromol.L (-1)) or Xestospongin C (3 micromol.L (-1)) or inhibiting phospholipase C and IP (3) formation using U73122 (5 micromol.L (-1)) or neomycin (1 and 4 mmol.L (-1)) reduced slow wave frequency, amplitude and duration. The mitochondrial uncouplers, p-trifluoromethoxy carbonyl phenyl hydrazone (1-10 micromol.L (-1)), carbonyl m-chlorophenylhydrazone (1-3 micromol.L (-1)) or rotenone (10 micromol.L (-1)), depolarized the membrane (8-10 mV) before abolishing electrical activity. |
1(0,0,0,1) | Details |
| 8882611 | Kengatharan M, De Kimpe SJ, Thiemermann C: Analysis of the signal transduction in the induction of synthase by lipoteichoic acid in macrophages. Br J Pharmacol. 1996 Mar;117(6):1163-70. A specific inhibitor of -phospholipase C (PC-PLC), D609, prevented the increase in formation (IC50 = 20 micrograms ml-1) caused by LTA. Inhibitors of the activation of the nuclear transcription factor NF-kappa B such as pyrrolidine dithiocarbamate (PDTC; an antioxidant and a metal chelator), butylated hydroxyanisole (BHA; an antioxidant), L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK), calpain inhibitor I (both I kappa B-protease inhibitors), or rotenone (an antioxidant which inhibits electron transport) prevented the nitrite formation stimulated by LTA. |
1(0,0,0,1) | Details |
| 11781140 | Gonzalez A, Schmid A, Salido GM, Camello PJ, Pariente JA: XOD-catalyzed ROS generation mobilizes from intracellular stores in mouse pancreatic acinar cells. Cell Signal. 2002 Feb;14(2):153-9. ROS still released Ca (2+) when the endoplasmic reticulum Ca (2+)-ATPase was blocked with thapsigargin (1 microM), or when rotenone (10 microM) was added to release Ca (2+) from mitochondria. |
0(0,0,0,0) | Details |