| Name | transferrin |
|---|---|
| Synonyms | Beta 1 metal binding globulin; PRO1400; PRO1557; PRO2086; Serotransferrin; Serotransferrin precursor; Siderophilin; TF… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 4416694 | Kailis SG, Morgan EH: Transferrin and iron uptake by rabbit bone marrow cells in vitro. Br J Haematol. 1974 Sep;28(1):37-52. |
1(0,0,0,1) | Details |
| 17469137 | Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. Using the AF5 neural-derived cell line, which displays GABAergic properties, we showed that Mn significantly increased release to 174%-214% of that of the control and that the effects of Mn exposure on the metabolism of and resembled the effects of fluorocitrate, an inhibitor of aconitase, but not the effects of other toxicants including paraquat, rotenone, or 3-nitropropionic acid. RNA mobility shift assay and Western blot showed that Mn treatment caused c-aconitase to be converted to iron regulatory protein 1 (IRP1) and increased the abundance of IRP2, leading to reduced H-ferritin expression, increased transferrin receptor expression, and increased uptake of transferrin. |
1(0,0,0,1) | Details |
| 2318295 | Zhan H, Gupta RK, Weaver J, Pollack S: bound to low MW ligands: interactions with mitochondria and cytosolic proteins. Eur J Haematol. 1990 Feb;44(2):125-31. However reticulocytes, treated with or rotenone and taking up iron from transferrin, accumulated iron in nonhaem cytosolic proteins and in mitochondria and not in the low MW pool. |
0(0,0,0,0) | Details |
| 6794942 | Bezkorovainy A, Topouzian N: The effect of metal chelators and other metabolic inhibitors on the growth of Bifidobacterium bifidus var. Clin Biochem. 1981 Jun;14(3):135-41. The following had no effect on its growth: serum transferrin, serum albumin, colchicine, - and rotenone. |
0(0,0,0,0) | Details |
| 2015269 | Qian ZM, Morgan EH: Effect of metabolic inhibitors on uptake of non-transferrin-bound iron by reticulocytes. Biochim Biophys Acta. 1991 Apr 9;1073(3):456-62. The relationship between transferrin-free iron uptake and cellular metabolism was investigated using rabbit reticulocytes in which energy metabolism was altered by incubation with metabolic inhibitors (antimycin A, 2,4-dinitrophenol, NaCN, NaN3 and rotenone) or substrates. |
35(0,1,1,5) | Details |
| 2379560 | Zhan H, Pollack S, Weaver J: Two pathways for iron uptake by guinea pig reticulocytes. . Eur J Haematol. 1990 Jul;45(1):15-8. We have demonstrated that the intracellular processing of transferrin to effect iron removal involves two pathways, one sensitive to rotenone and the other not. |
10(0,0,1,5) | Details |
| 831800 | Kailis SG, Morgan EH: uptake by immature erythroid cells. Biochim Biophys Acta. 1977 Jan 21;464(2):389-98. The mechanism by which the utilization of transferrin-bound iron is linked with cellular metabolism was investigated using rabbit reticulocytes and bone marrow cells. The rate of metabolism was altered by the use of inhibitors which act at different sites in the metabolic pathway (NaF, fluoroacetate, rotenone, 2,4-dinitrophenol, NaCN) and by the addition of metabolic substrates |
4(0,0,0,4) | Details |
| 19250966 | Mastroberardino PG, Hoffman EK, Horowitz MP, Betarbet R, Taylor G, Cheng D, Na HM, Gutekunst CA, Gearing M, Trojanowski JQ, Anderson M, Chu CT, Peng J, Greenamyre JT: A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis. 2009 Jun;34(3):417-31. Epub 2009 Feb 26. In the rotenone model of PD, Tf accumulates in neurons, with much of it accumulating in the mitochondria. |
2(0,0,0,2) | Details |
| 5809727 | Morgan EH, Baker E: The effect of metabolic inhibitors on transferrin and iron uptake and transferrin release from reticulocytes. Biochim Biophys Acta. 1969 Jul 30;184(2):442-54. |
1(0,0,0,1) | Details |
| 5000975 | Morgan EH: A study of iron transfer from rabbit transferrin to reticulocytes using synthetic chelating agents. Biochim Biophys Acta. 1971 Jul 20;244(1):103-16. |
1(0,0,0,1) | Details |
| 4407032 | Schulman HM, Martinez-Medellin J, Sidloi R: The reticulocyte-mediated release of iron and from transferrin: effect of metabolic inhibitors. Biochim Biophys Acta. 1974 May 24;343(3):529-34. |
1(0,0,0,1) | Details |
| 9186779 | Richardson DR: Mobilization of iron from neoplastic cells by some iron chelators is an energy-dependent process. Biochim Biophys Acta. 1997 May 16;1320(1):45-57. Interestingly, the metabolic inhibitors, 2,4-dinitrophenol, oligomycin, rotenone, and azide, markedly decreased 59Fe mobilization mediated by PIH, but had either no effect or much less effect on 59Fe release by 311. Initial experiments examined the release of 59Fe from SK-N-MC neuroblastoma (NB) cells prelabelled for 3 h at 37 degrees C with 59Fe-transferrin (1.25 microM) and then reincubated in the presence and absence of the chelators for 3 h at 4 degrees C or 37 degrees C. |
1(0,0,0,1) | Details |