| Name | phospholipase A2 |
|---|---|
| Synonyms | 14 3 3 protein zeta/delta; Phospholipase A2; KCIP 1; Protein kinase C inhibitor protein 1; 14 3 3 protein/cytosolic phospholipase A2; 14 3 3 zeta; FAS; Factor activating exoenzyme S… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 213108 | Feo F, Canuto RA, Garcea R, Brossa O: The role of lipid-protein interactions in -cytochrome c reductase (rotenone-insensitive) of rat liver mitochondria. Biochim Biophys Acta. 1978 Oct 11;504(1):1-14. The phospholipid depletion of rat liver mitochondria, induced by acetoneextraction or by digestion with phospholipase A2 or phospholipase C, greatly inhibited the activity of -cytochrome c reductase (rotenone-insensitive). |
32(0,1,1,2) | Details |
| 8171438 | Medrano CJ, Fox DA: Substrate-dependent effects of on rat retinal mitochondrial respiration: physiological and toxicological studies. Toxicol Appl Pharmacol. 1994 Apr;125(2):309-21. Isolated mitochondria were efficiently coupled; had good respiratory control ratios with the NAD-linked substrates, or plus (G/M or P/M), and the FAD-linked substrate, plus rotenone (S/R); and possessed a Na+/Ca2+ exchanger. Results with G/M suggest that Ca2+ acts on the inner membrane phospholipase A2 to decrease reductase activity and/or produce a NAD+ leak, whereas with S/R, Ca2+ may inhibit succinate dehydrogenase. |
1(0,0,0,1) | Details |
| 7529030 | Zulueta JJ, Yu FS, Hertig IA, Thannickal VJ, Hassoun PM: Release of peroxide in response to hypoxia-reoxygenation: role of an NAD (P) H oxidase-like enzyme in endothelial cell plasma membrane. Am J Respir Cell Mol Biol. 1995 Jan;12(1):41-9. Furthermore, inhibitors of cyclooxygenase (indomethacin), phospholipase A2 (quinacrine and chlorpromazine), synthase analogs), the mitochondrial electron transport chain (rotenone and and cytochrome P-450 (methoxypsoralen) had no or minimal effect on this release. |
0(0,0,0,0) | Details |
| 2332054 | Brustovetsky NN, Amerkhanov ZG, Popova EYu, Konstantinov AA: Reversible inhibition of electron transfer in the FEBS Lett. 1990 Apr 9;263(1):73-6. Partial release of the inhibition can be observed upon swelling of the isolated mitochondria in a hypoosmotic medium, the effect being prevented by phospholipase A2 inhibitors. |
2(0,0,0,2) | Details |
| 19737348 | Martin R, Hernandez M, Ibeas E, Fuentes L, Salicio V, Arnes M, Nieto ML: Secreted phospholipase A2-IIA modulates key regulators of proliferation on astrocytoma cells. J Neurochem. 2009 Nov;111(4):988-99. Epub 2009 Sep 8. We found that sPLA (2)-IIA promoted reactive species (ROS) accumulation, which was abrogated in the presence of allopurinol and DPI, but not by rotenone, discarding mitochondria as a ROS source. |
1(0,0,0,1) | Details |
| 7317523 | Agureev AP, Altukhov ND, Mokhova EN, Savel'ev IA: [Activation of the external pathway of oxidation in mitochondria at decreased pH]. Biokhimiia. 1981 Nov;46(11):1945-56. The results obtained are indicative of an existence of an external pathway of oxidation, which is insensitive to antimycin A and rotenone in skeletal muscle mitochondria. The external pathway of oxidation in liver mitochondria is sensitive to the inhibitors of phospholipase A2 (nupercaine, EGTA) and the inhibitor of lipid peroxidation (ionole). |
1(0,0,0,1) | Details |
| 8314748 | Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL: Cyclosporin and prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem. 1993 Jul 5;268(19):13791-8. Cyclosporin A (CyA) and (LC) prevented the killing of cultured hepatocytes by anoxia and rotenone but not by Cell killing by was prevented when the phospholipase A2 inhibitor butacaine was added together with CyA. |
1(0,0,0,1) | Details |
| 427130 | Kilberg MS, Christensen HN: Electron-transferring enzymes in the plasma membrane of the Ehrlich ascites tumor cell. Biochemistry. 1979 Apr 17;18(8):1525-30. The activity differed from that of the mitochondria in that it was not inhibited by rotenone or antimycin A. Detergents such as Triton X-100 or resulted in solubilization of the enzymatic activity, but phospholipase A2 did not. |
1(0,0,0,1) | Details |
| 15255947 | Vesce S, Kirk L, Nicholls DG: Relationships between levels and delayed deregulation in cultured cerebellar granule cells exposed continuously to J Neurochem. 2004 Aug;90(3):683-93. Oxidative stress of mitochondrial origin is readily detectable, as the inhibitors rotenone and antimycin A markedly increase levels with no effect on cytoplasmic-free Ca2+. Phospholipase A2 inhibitors decrease the deregulation-related increase in without protecting against deregulation. |
1(0,0,0,1) | Details |
| 11225736 | Li YP, Atkins CM, Sweatt JD, Reid MB: Mitochondria mediate tumor necrosis factor-alpha/NF-kappaB signaling in skeletal muscle myotubes. Antioxid Redox Signal. 1999 Spring;1(1):97-104. We found that activation of NF-kappaB by TNF-alpha was blocked by rotenone or amytal, inhibitors of complex I of the mitochondrial respiratory chain. |
0(0,0,0,0) | Details |