| Name | PP2A |
|---|---|
| Synonyms | PP2A; PP2A subunit B prime; PR53; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine protein phosphatase 2A regulatory subunit B'; PP2A subunit B primes… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18646208 | Maalouf M, Rho JM: Oxidative impairment of hippocampal long-term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies. J Neurosci Res. 2008 Nov 15;86(15):3322-30. We found that: 1) a combination of ACA and BHB (1 mM each) prevented impairment of LTP by H (2) O (2) (200 microM); 2) KB significantly lowered intracellular levels of reactive species (ROS)--measured with the fluorescent indicator carboxy-H (2) DCFDA (carboxy-2',7'-dichlorodihydrofluorescein --in CA1 pyramidal neurons exposed to H (2) O (2); 3) the effect of KB on LTP was replicated by the protein phosphatase 2A (PP2A) inhibitor fostriecin; 4) KB prevented impairment of LTP by the PP2A activator C (6) 5) fostriecin did not prevent the increase in ROS levels in CA1 pyramidal neurons exposed to H (2) O (2), and C (6) did not increase ROS levels; 6) PP2A activity was enhanced by both H (2) O (2) and rotenone (a mitochondrial complex I inhibitor that increases endogenous production); and 7) KB inhibited PP2A activity in protein extracts from brain tissue treated with either H (2) O (2) or We propose that oxidative impairment of hippocampal LTP is associated with PP2A activation, and that KB prevent this impairment in part by inducing PP2A inhibition through an antioxidant mechanism. |
1(0,0,0,1) | Details |
| 17651460 | Prigione A, Cortopassi G: Mitochondrial DNA deletions induce the -activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell. 2007 Oct;6(5):619-30. Epub 2007 Jul 26. Deletions caused a defect in the (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. The defects in ATP synthesis, induction of the AMPK and SREBF1 transcripts, and decreased expression of ARL2 and secretion of OPG and FN were recapitulated by low doses of rotenone, demonstrating that they were a specific consequence of electron transport chain inhibition. |
1(0,0,0,1) | Details |
| 18940801 | Dagda RK, Merrill RA, Cribbs JT, Chen Y, Hell JW, Usachev YM, Strack S: The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. J Biol Chem. 2008 Dec 26;283(52):36241-8. Epub 2008 Oct 21. PPP2R2B encodes Bbeta1 and Bbeta2, alternatively spliced and neuron-specific regulatory subunits of the protein phosphatase 2A (PP2A) holoenzyme. |
3(0,0,0,3) | Details |