| Name | statins |
|---|---|
| Synonyms | STN; statin; statins |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19504041 | Pienaar IS, Schallert T, Hattingh S, Daniels WM: Behavioral and quantitative mitochondrial proteome analyses of the effects of implications for models of neural degeneration. J Neural Transm. 2009 Jul;116(7):791-806. Epub 2009 Jun 6. Rats were pre-treated with for 14 days, followed by a single unihemispheric (substantia nigra; SN) injection of rotenone, a mitochondrial complex I inhibitor. Statins have been shown to protect neurons from degeneration in a number of animal models. |
2(0,0,0,2) | Details |
| 17361016 | Marroquin LD, Hynes J, Dykens JA, Jamieson JD, Will Y: Circumventing the Crabtree effect: replacing media with increases susceptibility of HepG2 cells to mitochondrial toxicants. Toxicol Sci. 2007 Jun;97(2):539-47. Epub 2007 Mar 14. Such anaerobically poised cells are resistant to xenobiotics that impair mitochondrial function, such as the inhibitors rotenone, antimycin, oligomycin, and compounds like carbonyl 4-(trifluoromethoxy) phenylhydrazone (FCCP), that uncouple the respiratory electron transfer system from phosphorylation. Drug-induced mitochondrial toxicity is shown by members of important drug classes, including the thiazolidinediones, statins, fibrates, antivirals, antibiotics, and anticancer agents. |
1(0,0,0,1) | Details |