| Name | Kir6.2 |
|---|---|
| Synonyms | ATP sensitive inward rectifier potassium channel II; ATP sensitive inward rectifier potassium channel 11; BIR; Beta cell inward rectifier subunit; HHF 2; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16837559 | Wu J, Hu J, Chen YP, Takeo T, Suga S, Dechon J, Liu Q, Yang KC, St John PA, Hu G, Wang H, Wakui M: Iptakalim modulates ATP-sensitive K (+) channels in neurons from rat substantia nigra pars compacta. J Pharmacol Exp Ther. 2006 Oct;319(1):155-64. Epub 2006 Jul 12. In identified DA neurons acutely dissociated from rat substantia nigra pars compacta (SNc), both the mitochondrial metabolic inhibitor rotenone and the sulfonylurea receptor subtype (SUR) 1-selective K (ATP) channel opener (KCO) diazoxide induced neuronal hyperpolarization and abolished action potential firing, but the SUR2B-selective KCO cromakalim exerted little effect, suggesting that functional K (ATP) channels in rat SNc DA neurons are mainly composed of SUR1. Furthermore, in human embryonic kidney 293 cells, iptakalim (300-500 microM) closed diazoxide-induced Kir6.2/SUR1 K (ATP) channels, which were heterologously expressed. |
1(0,0,0,1) | Details |
| 10022826 | Liss B, Bruns R, Roeper J: Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. EMBO J. 1999 Feb 15;18(4):833-46. In contrast to GABAergic neurons, single dopaminergic SN neurons displayed alternative co-expression of either SUR1, SUR2B or both SUR isoforms with Kir6.2. |
2(0,0,0,2) | Details |