| Name | aldose reductase |
|---|---|
| Synonyms | ADR; ALDR 1; ALDR1; Aldehyde reductase; AKR1B1; AKR1B1 protein; AR; Aldehyde reductase 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15598843 | Han HJ, Lee YJ, Park SH, Lee JH, Taub M: High glucose-induced oxidative stress inhibits Na+/ cotransporter activity in renal proximal tubule cells. Am J Physiol Renal Physiol. 2005 May;288(5):F988-96. Epub 2004 Dec 14. One consequence of excessive intracellular levels is an increased rate of oxidative phosphorylation under hyperglycemic conditions, whereas another consequence is an increase in the metabolism of to by aldose reductase. Pretreatment of the cultures with either 1) aminoguanidine or [inhibitors of the accumulation of advanced glycation end products (AGEs)], 2) rotenone (an inhibitor of the mitochondrial electron transport chain), or 3) apocynin or diphenylene iodonium (DPI; inhibitors of oxidase) blocked the observed changes that occurred as a consequence of the incubation of the PTCs with high |
1(0,0,0,1) | Details |
| 10783895 | Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M: Normalizing mitochondrial production blocks three pathways of hyperglycaemic damage. Nature. 2000 Apr 13;404(6779):787-90. Three seemingly independent biochemical pathways are involved in the pathogenesis: -induced activation of protein kinase C isoforms; increased formation of -derived advanced glycation end-products; and increased flux through the aldose reductase pathway. |
1(0,0,0,1) | Details |
| 10797558 | Lamensdorf I, Eisenhofer G, Harvey-White J, Hayakawa Y, Kirk K, Kopin IJ: Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde. J Neurosci Res. 2000 May 15;60(4):552-8. This is either oxidized to 3,4- by aldehyde dehydrogenase, an NAD-dependent enzyme or reduced to 3, 4-dihydroxyphenylethanol (DOPET) by or aldose reductase. |
1(0,0,0,1) | Details |
| 10854571 | Lamensdorf I, Eisenhofer G, Harvey-White J, Nechustan A, Kirk K, Kopin IJ: 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells. Brain Res. 2000 Jun 23;868(2):191-201. This is mainly oxidized to 3,4- by aldehyde dehydrogenase (ALDH), but is also partly reduced to 3, 4-dihydroxyphenylethanol (DOPET) by or aldose reductase (ARs). In a previous study, we found that rotenone, a complex I inhibitor, induced a rapid accumulation of DOPAL and DOPET in the medium of cultured PC12 cells. |
1(0,0,0,1) | Details |