| Name | Proton pumps |
|---|---|
| Synonyms | ATP4A; Cation transporting ATPase; ATP6A; Gastric H+/K+ ATPase alpha subunit; Gastric H+/K+ ATPase subunit alpha; Potassium transporting ATPase alpha chain 1; Proton pump; Gastric H+/K+ ATPase alpha subunits… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16651638 | Watanabe N, Zmijewski JW, Takabe W, Umezu-Goto M, Le Goffe C, Sekine A, Landar A, Watanabe A, Aoki J, Arai H, Kodama T, Murphy MP, Kalyanaraman R, Darley-Usmar VM, Noguchi N: Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive species generation in endothelial cells. Am J Pathol. 2006 May;168(5):1737-48. ERK activation was attenuated by inhibitors of the electron transport chain proton pumps (rotenone and antimycin A) and an uncoupler (carbonyl p-trifluoromethoxyphenylhydrazone), suggesting that mitochondrial inner membrane potential plays a key role in the signaling pathway. |
31(0,1,1,1) | Details |
| 6315077 | Marshanskii VN, Novgorodov SA, Iaguzhinskii LS: [Effect of specific inhibitors of the enzymes of the respiratory chain and -synthetase on ion transport in mitochondria induced by non-enzymic peroxide reactions]. Biofizika. 1983 Sep-Oct;28(5):830-4. Effect of specific inhibitors of membrane proton pumps of the respiratory chain and -synthetase on ionic permeability of mitochondrial membranes induced by bivalent ferrum ions or organic hydroperoxide was studied. |
2(0,0,0,2) | Details |
| 2450579 | Petronilli V, Azzone GF, Pietrobon D: Analysis of mechanisms of free-energy coupling and uncoupling by inhibitor titrations: theory, computer modeling and experiments. Biochim Biophys Acta. 1988 Mar 9;932(3):306-24. The rates of ATP synthesis and of ATP-driven NAD reduction have been measured in bovine heart submitochondrial particles as a function of the fraction of inhibited redox pumps (in titrations with either antimycin or rotenone) and of the fraction of inhibited ATPases (in titrations with DCCD). The flux control coefficients of the redox and ATPase proton pumps on the rates of ATP synthesis and of ATP-driven NAD reduction have been derived and found to be equal to 1 for both pumps; i.e., both pumps appear to be 'completely rate limiting'. |
2(0,0,0,2) | Details |
| 9739168 | Rottenberg H, Wu S: Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. Biochim Biophys Acta. 1998 Sep 16;1404(3):393-404. Only under these condition, the cell fluorescence appears to be correlated with the magnitude of DeltaPsim, as evident from the sensitivity of the fluorescence to low concentrations of uncouplers, ionophores and inhibitors of the mitochondrial proton pumps. |
1(0,0,0,1) | Details |