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Sosinski J, Thakar JH, Germain GS, Dias P, Harwood FC, Kuttesch JF, Houghton PJ: Cross-resistance to antitumor diarylsulfonylureas and collateral sensitivity to mitochondrial toxins in a human cell line selected for resistance to the antitumor agent N-(5-indanylsulfonyl)-N'-(4-chlorophenyl) urea. Mol Pharmacol. 1994 May;45(5):962-70.
In contrast, LYC5 cells were collaterally sensitive to the mitochondrial toxins rotenone, antimycin, and oligomycin, by 11.4-, 7.2-, and 36.9-fold respectively.
To further study these agents a subline of human colon carcinoma, GC3/c1, was selected for resistance to N-(5-indanylsulfonyl)-N'-(4-chlorophenyl) urea (ISCU) (Sulofenur). |
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