| Name | NA K ATPase |
|---|---|
| Synonyms | (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6086170 | Kramer JH, Mak IT, Weglicki WB: Differential sensitivity of canine cardiac sarcolemmal and microsomal enzymes to inhibition by free radical-induced lipid peroxidation. Circ Res. 1984 Jul;55(1):120-4. Sarcolemmal and microsomal membranes prepared from adult canine cardiac myocytes (sarcolemmal Na+, K+-ATPase = 71.8 mumol/mg per hr and microsomal rotenone-insensitive cytochrome c reductase = 114 mumol/mg per hr) were each preincubated at 37 degrees C in the presence of a free radical generating system consisting of and Fe - loss of the Na+, K+-ATPase and reductase activities, as well as the associated increases in lipid peroxidation, measured by malondialdehyde formation, were temporally correlated in both systems. |
6(0,0,1,1) | Details |
| 2450579 | Petronilli V, Azzone GF, Pietrobon D: Analysis of mechanisms of free-energy coupling and uncoupling by inhibitor titrations: theory, computer modeling and experiments. Biochim Biophys Acta. 1988 Mar 9;932(3):306-24. The rates of ATP synthesis and of ATP-driven NAD reduction have been measured in bovine heart submitochondrial particles as a function of the fraction of inhibited redox pumps (in titrations with either antimycin or rotenone) and of the fraction of inhibited ATPases (in titrations with DCCD). |
81(1,1,1,1) | Details |
| 9777020 | Kuwahara S, Chin S, Delamere NA: Partial inhibition of Na,K-ATPase activity in cultured rabbit non-pigmented ciliary epithelium following an episode of cytoplasmic ATP depletion. Acta Physiol Scand. 1998 Sep;164(1):13-20. In keeping with this suggestion, diminished Na,K-ATPase activity was observed in cells that had been pre-treated 20 min with the metabolic inhibitors CCCP or rotenone and in cells pre-treated 2.5 h in -free medium. |
35(0,1,1,5) | Details |
| 8023940 | Del Castillo JR, Sulbaran-Carrasco MC, Burguillos L: K+ transport in isolated guinea pig colonocytes: evidence for Na (+)-independent ouabain-sensitive K+ pump. Am J Physiol. 1994 Jun;266(6 Pt 1):G1083-9. These transport mechanisms are sensitive to metabolic inhibition by rotenone and to vanadate, a blocker of type P adenosinetriphosphatase (ATPases). |
31(0,1,1,1) | Details |
| 19442964 | Yin W, Li X, Feng S, Cheng W, Tang B, Shi YL, Hua ZC: Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism. Biochem Pharmacol. 2009 Jul 15;78(2):191-202. Epub 2009 Apr 5. Rotenone-induced PMP depolarization occurred before apoptosis and well correlated with Na,K-ATPase impairment. |
17(0,0,2,7) | Details |
| 2986257 | Weglicki WB, Kramer JH, Kennett FF, Knauer TE, Owens K: Perturbations of sarcolemmal and microsomal enzymes by amphiphilic lipids and drugs. Adv Myocardiol. 1985;6:127-36. SL Na+, K+-ATPase (2.35 mumole/min per mg) was enriched 117-fold over the homogenate and MC rotenone-insensitive cytochrome c reductase (RINCR) was enriched 41-fold. |
8(0,0,1,3) | Details |
| 16624565 | Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Bernardi G, Shen J, Calabresi P: Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis. 2006 Jul;23(1):54-60. Epub 2006 Apr 19. We assessed the responses of dopaminergic cells to combined and deprivation (OGD), and to the mitochondrial toxin rotenone. |
3(0,0,0,3) | Details |
| 2425627 | Tessitore N, Sakhrani LM, Massry SG: Quantitative requirement for ATP for active transport in isolated renal cells. Am J Physiol. 1986 Jul;251(1 Pt 1):C120-7. We investigated the quantitative relationship between cellular ATP concentration and Na+-K+-ATPase activity as measured by ouabain-sensitive 86Rb influx in rabbit proximal renal cells. Cellular ATP was reduced in a stepwise manner by rotenone (10 (-7) to 10 (-5) M) and was increased by 10 mM |
3(0,0,0,3) | Details |
| 135642 | McCoy GD, Racker E: Protein synthesis in dextran -treated ascites tumor cells. . Cancer Res. 1976 Sep;36(9 pt.1):3346-9. Rotenone inhibited the reaction, which could be restored by addition of both inorganic and either or an inhibitor of the Na+-K+-ATPase, markedly depressed the incorporation of [14C] into protein in intact sdviyrd tumor cells in a high Na+ medium. |
2(0,0,0,2) | Details |
| 2997289 | Brazy PC, Trellis DR, Klotman PE: Bradykinin stimulation of oxidative metabolism in renal cortical tubules from rabbit. J Clin Invest. 1985 Nov;76(5):1812-8. This stimulation was prevented by -free media or by the addition of inhibitors of transport, -calmodulin complex formation, Na,K-ATPase activity, mitochondrial respiration, and phospholipase activity. |
2(0,0,0,2) | Details |
| 9067905 | Zager RA, Burkhart K: Myoglobin toxicity in proximal human kidney cells: roles of Fe, Ca2+, H2O2, and terminal mitochondrial electron transport. Kidney Int. 1997 Mar;51(3):728-38. Blockade of site 2 (antimycin) and site 3 (azide), but not site 1 (rotenone), mitochondrial electron transport significantly reduced myoglobin cytotoxicity. Inhibition of Na, K-ATPase driven respiration (ouabain) produced a similar protective effect. |
1(0,0,0,1) | Details |
| 6094706 | Soltoff SP, Mandel LJ: Active ion transport in the renal proximal tubule. J Gen Physiol. 1984 Oct;84(4):643-62. Rotenone (an inhibitor of mitochondrial oxidative phosphorylation) was used in graded fashion to alter the cellular ATP, and the Na pump activity was measured when the pump was stimulated by adding KCl to tubules suspended in a K+-free medium. However, the Na,K-ATPase hydrolytic activity (assayed biochemically) of lysed proximal tubule membranes demonstrated saturation and had a K0.5 value of 0.4 mM ATP. |
1(0,0,0,1) | Details |
| 6331176 | Gullans SR, Brazy PC, Dennis VW, Mandel LJ: Interactions between gluconeogenesis and transport in rabbit proximal tubule. Am J Physiol. 1984 Jun;246(6 Pt 2):F859-69. Increasing Na-K-ATPase activity with nystatin or decreasing it with ouabain had widely differing effects, which also depended on the substrate regimen. Inhibition of ATP production with rotenone, which we have previously shown to inhibit Jv [Am. |
1(0,0,0,1) | Details |
| 1880454 | Borrelli MJ, Rausch CM, Seaner R, Iliakis G: Sensitization to hyperthermia by 3,3'-dipentyloxacarbocyanine iodide: a positive correlation with DNA damage and negative correlations with altered cell morphology, consumption inhibition, and reduced ATP levels. Int J Hyperthermia. 1991 Mar-Apr;7(2):243-61. It inhibits electron transport, uncouples oxidative phosphorylation, and inhibits ATPases. |
1(0,0,0,1) | Details |
| 3688218 | Murphy E, LeFurgey A, Lieberman M: Biochemical and structural changes in cultured heart cells induced by metabolic inhibition. Am J Physiol. 1987 Nov;253(5 Pt 1):C700-6. We examined the relationship between ionic homeostasis, ATP, and irreversible cell injury in cultured embryonic chick heart cells treated with rotenone (10 (-4) M) alone or in combination with iodoacetate (IAA) (10 (-3) M), in the presence of extracellular (Ca0) (2.7 mM) and its nominal absence. Thus Ca0 appears to promote Nai-Ca0 exchange and lead to an increase in cell Ca that can then stimulate ATP breakdown by Ca-activated ATPases. |
1(0,0,0,1) | Details |
| 8105040 | Madl JE, Burgesser K: depletion reverses -dependent, neuronal uptake of in rat hippocampal slices. J Neurosci. 1993 Oct;13(10):4429-44. ATP depletion and ouabain acted synergistically to produce EAA release, strongly suggesting release was largely mediated by inhibition of Na/K-ATPases. |
1(0,0,0,1) | Details |
| 2539729 | Kone BC, Kikeri D, Zeidel ML, Gullans SR: Cellular pathways of transport in renal inner medullary collecting duct. Am J Physiol. 1989 Apr;256(4 Pt 1):C823-30. Thus K+ transport in the IMCD occurs principally via Ba2+ -sensitive K+ conductive pathway (s) and Na+-K+-ATPase. However, inhibition of mitochondrial oxidative phosphorylation with rotenone demonstrated that glycolysis alone could not maintain cell K+ content. |
1(0,0,0,1) | Details |
| 3202180 | Gullans SR, Kone BC, Avison MJ, Giebisch G: alters respiration, membrane potential, and intracellular K+ in proximal tubule. Am J Physiol. 1988 Dec;255(6 Pt 2):F1170-7. Thus the cellular entry and metabolism of promotes multiple changes in ion transport without altering Na+-K+-ATPase activity. |
1(0,0,0,1) | Details |
| 14676274 | Baker MA, Hetherington L, Ecroyd H, Roman SD, Aitken RJ: Analysis of the mechanism by which negatively regulates the phosphorylation cascade associated with sperm capacitation. J Cell Sci. 2004 Jan 15;117(Pt 2):211-22. Addition of the affinity-labeling probe 8-N3 ATP confirmed our prediction that spermatozoa have many -dependent ATPases. In contrast, the mitochondrial inhibitor rotenone had no effect on either ATP levels or phosphorylation. |
1(0,0,0,1) | Details |
| 1313342 | Piwnica-Worms D, Chiu ML, Kronauge JF: Divergent kinetics of 201Tl and 99mTc-SESTAMIBI in cultured chick ventricular myocytes during ATP depletion. Circulation. 1992 Apr;85(4):1531-41. Initial myocellular uptake rates of 201Tl reflect activity of Na,K-ATPase, whereas those of 99mTc-SESTAMIBI reflect mean plasma membrane potential. METHODS AND RESULTS: To better understand the mechanistic responses of these tracers to myocellular injury, cultured chick embryo cardiac myocytes were metabolically inhibited in iodoacetate (1 mM) and rotenone (10 microM) for up to 2 hours, and initial uptake rates of each agent were determined at successive intervals along with correlative cellular contents of ATP, and and lactate dehydrogenase release. |
1(0,0,0,1) | Details |
| 16706167 | Rakhmatullina DF, Gordon LKh, Ogorodnikova TI: [Respiration of wheat root cells under simultaneous inhibition of parts I and III of the electron transport chain of mitochondria by rotenone and antimycine A]. Tsitologiia. 2005;47(3):230-6. Participation of ATPases and redox system of plasma membrane in the response reactions of respiration directed to the restoration of ion, particularly, homeostasis in conditions of inhibited mitochondrial oxidation is discussed. |
1(0,0,0,1) | Details |
| 4009171 | Gonatas JO, Gonatas NK, Stieber A, Fleischer B: Isolation and characterization of an enriched Golgi fraction from neurons of developing rat brains. J Neurochem. 1985 Aug;45(2):497-507. The activities of the possible marker enzymes rotenone-insensitive -cytochrome c reductase, -cytochrome c reductase, and arylsulfatase were low or minimally elevated in the Golgi fractions. A sevenfold enrichment of Na+, K+-ATPase activities was found in the Golgi fractions. |
1(0,0,0,1) | Details |
| 9813265 | Yamakami J, Sakurai E, Sakurada T, Maeda K, Hikichi N: Stereoselective blood-brain barrier transport of in rats. Brain Res. 1998 Nov 23;812(1-2):105-12. A decrease in incubation temperature from 37 to 0 degreesC or the addition of metabolic inhibitors (DNP and rotenone) reduced the uptake rate of Ouabain, an inhibitor of (Na+, K+)-ATPase, also reduced uptake of |
1(0,0,0,1) | Details |
| 16663354 | Marin B: Sensitivity of Tonoplast-Bound -Triphosphatase from Hevea to Inhibitors. Plant Physiol. 1983 Dec;73(4):973-977. The inhibitors of the mitochondrial ATPase, oligomycin and azide, and also rotenone and antimycin A, were all without effect. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline was also an efficient inhibitor.This unique inhibitor sensitivity of the Hevea tonoplast H (+)-translocating ATPase suggests that this enzyme differs in its mode of operation from all other known H (+)-translocating ATPases. |
1(0,0,0,1) | Details |
| 3303974 | Stokes JB, Grupp C, Kinne RK: Purification of rat papillary collecting duct cells: functional and metabolic assessment. Am J Physiol. 1987 Aug;253(2 Pt 2):F251-62. As assessed by binding of the lectin Dolichos biflorus and determination of -sensitive adenylate cyclase and Na+-K+-ATPase, the enrichment of PCD cells over a crude papillary cell preparation was 1.8, 2.4, and 1.4, respectively. In the presence of rotenone, glycolysis increased by 56% and was able to maintain the cellular ATP level at 65% of control. |
1(0,0,0,1) | Details |
| 2972256 | Hammerstedt RH, Volonte C, Racker E: Motility, heat, and lactate production in ejaculated bovine sperm. . Arch Biochem Biophys. 1988 Oct;266(1):111-23. Effects of various inhibitors on motility, heat, and lactate production of ejaculated bovine sperm were determined in the presence of antimycin A and rotenone. erythro-9-[3-(2-Hydroxynonyl)] (EHNA) and polyvinylpyrrolidone (PVP-360) stopped motility and reduced heat or lactate production by 30-50%. |
0(0,0,0,0) | Details |