Protein Information

Name proline dehydrogenase
Synonyms HSPOX 2; HSPOX2; P53 induced protein; PIG 6; PIG6; PRODH; PRODH protein; PRODH 1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
10425713 Obungu VH, Kiaira JK, Njogu RM, Olembo NK: Catabolism of proline by procyclic culture forms of Trypanosoma congolense. Comp Biochem Physiol B Biochem Mol Biol. 1999 May;123(1):59-65.

Rotenone had no effect on the rate of respiration except when the intact cells were first permeabilized by digitonin after which rotenone decreased the rate of respiration by 20-30%.
Enzymes involved in the catabolism of proline with high activities were: proline dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, fumarase, NADP-linked malic enzyme, alanine aminotransferase and malate dehydrogenase.
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7318831 Mommsen TP, Hochachka PW: Respiratory and enzymatic properties of squid heart mitochondria. . Eur J Biochem. 1981 Nov;120(2):345-50.

Rotenone inhibited state-3 respiration of malate, proline, ornithine and pyrroline carboxylate.
Key enzymes in proline and ornithine oxidation, i.e. proline dehydrogenase, pyrroline-carboxylate dehydrogenase, ornithine aminotransferase, and glutamate dehydrogenase were located in the mitochondria.
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