| Name | PARP 1 |
|---|---|
| Synonyms | DDF 1; PARP 1; DDF1; PARP 7; PARP7; TCDD inducible poly ADP ribose polymerase; TCDD inducible poly(ADP ribose) polymerase; TIPARP… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17947304 | Duan Y, Gross RA, Sheu SS: Ca2+-dependent generation of mitochondrial reactive species serves as a signal for poly (ADP- polymerase-1 activation during excitotoxicity. J Physiol. 2007 Dec 15;585(Pt 3):741-58. Epub 2007 Oct 18. Mitochondrial Ca (2+) uptake and poly (ADP- polymerase-1 (PARP-1) activation are both required for -induced excitotoxic neuronal death. This ROS increase was inhibited by the mitochondrial complex inhibitors rotenone and oligomycin, but not by the cytosolic phospholipase A (2) or xanthine oxidase inhibitors. |
4(0,0,0,4) | Details |
| 18817777 | Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D: Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Lett. 2008 Oct 29;582(25-26):3601-6. Epub 2008 Sep 24. We noted that PM enhanced human CF bronchial epithelial apoptosis, activated caspase-9 and PARP-1; and reduced mitochondrial membrane potential. Mitochondrial inhibitors (4,4-diisothiocyanatostilbene-2,2'disulfonic acid, rotenone and thenoyltrifluoroacetone) blocked PM-induced generation of reactive species and apoptosis. |
1(0,0,0,1) | Details |