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Artwohl M, Furnsinn C, Waldhausl W, Holzenbein T, Rainer G, Freudenthaler A, Roden M, Baumgartner-Parzer SM: Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. Epub 2005 Feb 24.
Whereas p21WAF-1/Cip1 and p27Kip were differently affected in HUVECs, all agents reduced (p <0.05) expression of cyclins (D3, A, E, B), cyclin-dependent kinase-2 and hyperphosphorylated retinoblastoma protein.
Proliferation inhibition and lactate release were mimicked by rotenone (mitochondrial complex I inhibitor). |
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