Protein Information

Name cytosolic malate dehydrogenase
Synonyms Cytosolic malate dehydrogenase; MDH 1; MDH s; MDH1; MDHA; MOR 2; MOR2; Malate dehydrogenase cytoplasmic…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19670830 Mali Y, Zisapel N: A novel decoy that interrupts G93A-superoxide dismutase gain of interaction with malate dehydrogenase improves survival in an amyotrophic lateral sclerosis cell model. J Med Chem. 2009 Sep 10;52(17):5442-8.

Recent observations indicate gain of interaction of G93AhSOD1 with cytosolic malate dehydrogenase (MDH1) and subsequent impairment in the malate aspartate shuttle which is vital to neurons.
A cell permeable 5-carboxytetramethylrhodamine derivative of the decoy peptide improved ATP content of motor neuron derived NSC-34 cells expressing G93AhSOD1 and enhanced cell survival under rotenone and low glucose challenges.
3(0,0,0,3) Details
16661455 Rustin P, Moreau F, Lance C: Malate Oxidation in Plant Mitochondria via Malic Enzyme and the Cyanide-insensitive Electron Transport Pathway. Plant Physiol. 1980 Sep;66(3):457-462.

In cauliflower, mitochondria malate oxidation via malate dehydrogenase is rotenone- and cyanide-sensitive.
Both enzymes are located in the matrix, but some experimental data also suggest that part of malate dehydrogenase activity is also present outside the matrix compartment (adsorbed cytosolic malate dehydrogenase?).
1(0,0,0,1) Details