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Dedov VN, Mandadi S, Armati PJ, Verkhratsky A: Capsaicin-induced depolarisation of mitochondria in dorsal root ganglion neurons is enhanced by vanilloid receptors. Neuroscience. 2001;103(1):219-26.
The presence of vanilloid receptor-1 in DRG neurons makes their mitochondria 20-30-fold more sensitive to the depolarising effect of capsaicin compared with non-neuronal cells lacking vanilloid receptor-1.
Rotenone, an inhibitor of complex I of the mitochondrial respiratory chain, and oligomycin, an inhibitor of F (0) F (1)-ATPase, significantly enhanced the mitochondrial depolarisation produced by capsaicin in DRG neurons. |
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