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Cuchillo-Ibanez I, Lejen T, Albillos A, Rose SD, Olivares R, Villarroya M, Garcia AG, Trifaro JM: Mitochondrial calcium sequestration and protein kinase C cooperate in the regulation of cortical F-actin disassembly and secretion in bovine chromaffin cells. J Physiol. 2004 Oct 1;560(Pt 1):63-76. Epub 2004 May 7.
CCCP also enhanced the phosphorylation of PKC and myristoylated alanine-rich C kinase substance (MARCKS), and these were also inhibited by chelerythrine.
In addition, rotenone and oligomycin A, two other mitochondrial inhibitors, also evoked cortical F-actin disassembly and potentiated secretion; again, these effects were blocked by chelerythrine. |
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