| Name | 3 hydroxy 3 methylglutaryl coenzyme A reductase |
|---|---|
| Synonyms | 3 Hydroxy 3 methylglutaryl CoA reductase; 3 Hydroxy 3 methylglutaryl Coenzyme A reductase; Beta hydroxy beta methyl glutaryl CoA reductase; HMG CoA reductase; HMG Coenzyme A reductase; HMGCR; 3 Hydroxy 3 methylglutaryl Coenzyme A reductases; Beta hydroxy beta methyl glutaryl CoA reductases… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8263769 | Tsuji A, Saheki A, Tamai I, Terasaki T: Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier. J Pharmacol Exp Ther. 1993 Dec;267(3):1085-90. The uptake of HMG- reductase inhibitors with the lactone form, [14C] lovastatin and [14C] was slightly decreased to 65% of the control uptake (37 degrees C) at low temperature (4 degrees C) and was not affected by pretreatment of the BCEC with metabolic inhibitors (2,4-dinitrophenol and rotenone). [14C] acid (the lactone ring-opened form) was taken up in a markedly temperature- and concentration-dependent fashion, whereas the uptake of [14C] was negligible. |
1(0,0,0,1) | Details |
| 19504041 | Pienaar IS, Schallert T, Hattingh S, Daniels WM: Behavioral and quantitative mitochondrial proteome analyses of the effects of implications for models of neural degeneration. J Neural Transm. 2009 Jul;116(7):791-806. Epub 2009 Jun 6. Rats were pre-treated with for 14 days, followed by a single unihemispheric (substantia nigra; SN) injection of rotenone, a mitochondrial complex I inhibitor. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is used for lowering elevated low-density lipoprotein concentrations. |
1(0,0,0,1) | Details |
| 12952856 | Zager RA, Johnson AC, Hanson SY: Proximal tubular loading after mitochondrial, but not glycolytic, blockade. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1092-9. Epub 2003 Sep 2. Four or 18 h later, cell levels, reductase (HMGCR), the LDL receptor (LDL-R), and ABCA1/SR-B1 transporters were assessed. |
4(0,0,0,4) | Details |