| Name | glucose 6 phosphate dehydrogenase |
|---|---|
| Synonyms | 6 phosphogluconolactonase; GDH; G6PDH; Glucose 6 phosphate dehydrogenase; GDH/6PGL endoplasmic bifunctional protein; GDH/6PGL endoplasmic bifunctional protein precursor; Glucose 1 dehydrogenase; Glucose dehydrogenase… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8307034 | Friedrich T, van Heek P, Leif H, Ohnishi T, Forche E, Kunze B, Jansen R, Trowitzsch-Kienast W, Hofle G, Reichenbach H, et al.: Two binding sites of inhibitors in oxidoreductase (complex I). Eur J Biochem. 1994 Jan 15;219(1-2):691-8. The effect of ten naturally occurring and two synthetic inhibitors of NADH:ubiquinone oxidoreductase (complex I) of bovine heart, Neurospora crassa and Escherichia coli and glucose:ubiquinone oxidoreductase (glucose dehydrogenase) of Gluconobacter oxidans was investigated. Class II inhibitors including the naturally occurring rotenone, phenoxan, aureothin and the synthetic benzimidazole inhibit complex I from all species in an non-competitive manner, but have no effect on the glucose dehydrogenase. |
3(0,0,0,3) | Details |
| 19429815 | Serpillon S, Floyd BC, Gupte RS, George S, Kozicky M, Neito V, Recchia F, Stanley W, Wolin MS, Gupte SA: production by NAD (P) H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H153-62. Epub 2009 May 8. The role of glucose-6-phosphate dehydrogenase-derived O (2)(-) levels were elevated (70-90%; P < 0.05) in the diabetic heart, and this elevation was blocked by the Nox inhibitor gp-91 (ds-tat) (50 microM) or by the mitochondrial respiratory chain inhibitors antimycin (10 microM) and rotenone (50 microM). |
2(0,0,0,2) | Details |
| 623294 | Richardson DK, Czech MP: Primary role of decreased fatty acid synthesis in insulin resistance of large rat adipocytes. Am J Physiol. 1978 Feb;234(2):E182-9. Furthermore, inhibition of mitochondrial oxidation and fatty acid synthesis in small cells by rotenone led to a secondary inhibition of shunt activity indicating a link between these two pathways. |
0(0,0,0,0) | Details |
| 9377792 | Ribeiro SM, Campello AP, Nascimento AJ, Kluppel ML: Effect of amiodarone (AMD) on the antioxidant enzymes, lipid peroxidation and mitochondrial metabolism. Cell Biochem Funct. 1997 Sep;15(3):145-52. The results confirm the effects of AMD on complex I and permit the placing of this drug in class A of the classification of Knobeloch, together with rotenone, amytal and chaotropic agents. |
0(0,0,0,0) | Details |
| 6317750 | Kiyotaki C, Peisach J, Bloom BR: metabolism in cloned macrophage cell lines: dependence of production, metabolic and spectral analysis. J Immunol. 1984 Feb;132(2):857-66. O2- production in J774.16 cells was inhibited by some agents known to block mitochondrial electron transport before such as rotenone and tetrathiafulvalene, whereas antimycin A enhanced O2- production. |
0(0,0,0,0) | Details |
| 4404963 | Kather H, Rivera M, Brand K: Interrelationship and control of metabolism and lipogenesis in isolated fat-cells. Biochem J. 1972 Aug;128(5):1097-102. Rotenone, which is known to inhibit electron transport in the respiratory chain, blocked breakdown at the site of pyruvate dehydrogenase. |
0(0,0,0,0) | Details |