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Schafer M, Ewald N, Schafer C, Stapler A, Piper HM, Noll T: Signaling of hypoxia-induced autonomous proliferation of endothelial cells. FASEB J. 2003 Mar;17(3):449-51. Epub 2003 Jan 21.
In cultured endothelial cells of porcine aorta, we analyzed the signaling and compared hypoxia with mitochondrial inhibition by rotenone.
Hypoxia induced transient activation of p42 MAPK (phosphorylation rose from 11+/-5 to 51+/-7%), followed by translocation of p42 MAPK into the nucleus. |
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