| Name | cAMP dependent protein kinase (protein family or complex) |
|---|---|
| Synonyms | Protein kinase A; cAMP dependent protein kinase; cAMP dependent protein kinases |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18766020 | Gao XF, Wang W, He C: Rotenone inhibits delayed rectifier K+ current via a protein kinase A-dependent mechanism. Neuroreport. 2008 Sep 17;19(14):1401-5. |
143(1,3,3,3) | Details |
| 11342529 | Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, Brownlee M: Leptin induces mitochondrial production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem. 2001 Jul 6;276(27):25096-100. Epub 2001 May 7. Rotenone, thenoyltrifluoroacetone (TTFA), carbonyl m-chlorophenylhydrazone (CCCP), Mn (III) tetrakis (4- (MnTBAP), uncoupling protein-1 (UCP1) HVJ-liposomes, or manganese superoxide dismutase (MnSOD) HVJ-liposomes completely prevented the effect of leptin, suggesting that ROS arise from mitochondrial electron transport. |
2(0,0,0,2) | Details |
| 9115718 | Leclerc P, Gagnon C: Phosphorylation of Triton X-100 soluble and insoluble protein substrates in a demembranated/reactivated human sperm model. Mol Reprod Dev. 1996 Jun;44(2):200-11. Proteins phosphorylation during the reactivation of demembranated spermatozoa previously immobilized H2O2, + xanthine oxidase-generated reactive species, or the oxidative phosphorylation uncoupler rotenone, revealed increases in cAMP-independent phosphorylation of proteins of 16.2, 46, and 93 kDa. Phosphorylation of 2 proteins (36 and 51 kDa) was stimulated by cAMP in a concentration-dependent manner, and this increase was prevented by inhibitors of cAMP-dependent protein kinase. |
2(0,0,0,2) | Details |
| 6329280 | Suematsu E, Hirata M, Kuriyama H: Effects of cAMP- and -dependent protein kinases, and calmodulin on Ca2+ uptake by highly purified sarcolemmal vesicles of vascular smooth muscle. Biochim Biophys Acta. 1984 Jun 13;773(1):83-90. In these fractions, there was a high activity of 5'-nucleotidase, a putative marker enzyme of plasma membrane, and a low activity of rotenone insensitive -cytochrome c reductase a marker of sarcoplasmic reticulum. The cAMP-dependent protein kinase enhanced the phosphorylation of 28 and 22 kDa proteins, while the -dependent protein kinase phosphorylated the 35 kDa protein. |
1(0,0,0,1) | Details |
| 11181577 | Petruzzella V, Vergari R, Puzziferri I, Boffoli D, Lamantea E, Zeviani M, Papa S: A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome. Hum Mol Genet. 2001 Mar 1;10(5):529-35. Phosphorylation of this subunit by cAMP-dependent protein kinase has previously been found to activate the complex. Fibroblast cultures from the patient exhibited severe reduction of the rotenone-sensitive --> UQ oxidoreductase activity of complex I, which was insensitive to cAMP stimulation. |
1(0,0,0,1) | Details |