| Name | optic atrophy 1 |
|---|---|
| Synonyms | NPG; OPA 1; OPA1; NTG; Optic atrophy 1; Optic atrophy protein 1; largeG; optic atrophy 1 (autosomal dominant)… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19076450 | Knott AB, Bossy-Wetzel E: Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. Ann N Y Acad Sci. 2008 Dec;1147:283-92. Rotenone, a pesticide and inducer of PD symptoms, and amyloid-beta peptide, which is causally linked to Alzheimer's disease, initiate mitochondrial fission. First, hereditary mutations in the mitochondrial fusion GTPases optic atrophy-1 and mitofusin-2 cause neuropathies in humans. |
1(0,0,0,1) | Details |