| Name | glyceraldehyde 3 phosphate dehydrogenase |
|---|---|
| Synonyms | CDABP0047; G3PD; GAPD; GAPD protein; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; GAPD proteins; Glyceraldehyde 3 phosphate dehydrogenases |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19445904 | Huang J, Hao L, Xiong N, Cao X, Liang Z, Sun S, Wang T: Involvement of glyceraldehyde-3-phosphate dehydrogenase in rotenone-induced cell apoptosis: relevance to protein misfolding and aggregation. Brain Res. 2009 Jul 7;1279:1-8. Epub 2009 May 13. We found that rotenone, a common mitochondrial complex I inhibitor used to produce experimental parkinsonism, cannot only induce GAPDH translocation but also trigger intermolecular disulfide bonding and result in the formation of intracytoplasmic aggregates of GAPDH. |
89(1,1,2,4) | Details |
| 15794752 | Falchi AM, Isola R, Diana A, Putzolu M, Diaz G: Characterization of depolarization and repolarization phases of mitochondrial membrane potential fluctuations induced by tetramethylrhodamine methyl ester photoactivation. FEBS J. 2005 Apr;272(7):1649-59. The frequency of R phases was significantly inhibited by oligomycin and aurovertin (mitochondrial ATP synthase inhibitors), rotenone (mitochondrial complex I inhibitor) and iodoacetic acid (inhibitor of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase). |
81(1,1,1,1) | Details |
| 11205140 | Waldmeier PC, Boulton AA, Cools AR, Kato AC, Tatton WG: Neurorescuing effects of the GAPDH ligand CGP 3466B. J Neural Transm Suppl. 2000;(60):197-214. In concentrations ranging from 10 (-13)-10 (-5) M, it rescues partially differentiated PC12 cells from apoptosis induced by trophic withdrawal, cerebellar granule cells from apoptosis induced by cytosine arabinoside, rat embryonic mesencephalic dopaminergic cells from death caused by MPP+, and PAJU human neuroblastoma cells from death caused by rotenone. |
2(0,0,0,2) | Details |
| 7898611 | Sabri MI: Attenuation of glyceraldehyde-3-phosphate dehydrogenase activity and ATP levels in rat brain synaptosomes by acrylamide. Neurochem Res. 1994 Nov;19(11):1439-44. The effect of known inhibitors of glycolysis-iodoacetic acid (IAA), and of oxidative phophorylation-rotenone and antimycin A, was also studied on ATP synthesis by the synaptosomes. |
2(0,0,0,2) | Details |
| 10630619 | Wang C, Youssef J, Saran B, Rothberg PG, Cunningham ML, Molteni A, Badr M: Diminished energy metabolism and enhanced apoptosis in livers of B6C3F1 mice treated with the antihepatocarcinogen rotenone. Mol Cell Biochem. 1999 Nov;201(1-2):25-32. |
0(0,0,0,0) | Details |
| 15213233 | Takahashi H, Tran PO, LeRoy E, Harmon JS, Tanaka Y, Robertson RP: causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways. J Biol Chem. 2004 Sep 3;279(36):37316-23. Epub 2004 Jun 22. Neither rotenone or myxothiazol prevented D-GLYC-induced increases in islet ROS. |
0(0,0,0,0) | Details |