Protein Information

Name IL 1 alpha
Synonyms Hematopoietin 1; IL 1 alpha; IL 1A; IL1; IL1 alpha; IL1A; IL1F1; Interleukin 1 alpha…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
8658528 Corsini E, Bruccoleri A, Marinovich M, Galli CL: Endogenous interleukin-1 alpha associated with skin irritation induced by tributyltin. Toxicol Appl Pharmacol. 1996 Jun;138(2):268-74.

The complex-1 inhibitor rotenone also significantly inhibits IL-1alpha production.
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16120427 Blanco FJ, Lopez-Armada MJ, Maneiro E: Mitochondrial dysfunction in osteoarthritis. . Mitochondrion. 2004 Sep;4(5-6):715-28. Epub 2004 Oct 1.


Inhibition of complex I with rotenone increases the expression and synthesis of Bcl-2 and Cox-2, both effects are similar effects to produced by IL-1 in human chondrocytes.
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