| Name | endonuclease G |
|---|---|
| Synonyms | ENDOG; Endo G; Endonuclease G; Endo Gs; Endonuclease Gs |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15182854 | Lemarie A, Lagadic-Gossmann D, Morzadec C, Allain N, Fardel O, Vernhet L: Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Free Radic Biol Med. 2004 Jun 15;36(12):1517-31. Production of reactive species was inhibited by ruthenium red and rotenone, two mitochondrial inhibitors, and by diphenyleneiodonium, a flavoprotein inhibitor, which also prevented both loss in mitochondrial membrane potential and apoptosis. |
3(0,0,0,3) | Details |
| 17581813 | Marella M, Seo BB, Matsuno-Yagi A, Yagi T: Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line. J Biol Chem. 2007 Aug 17;282(33):24146-56. Epub 2007 Jun 20. We have shown that expression of a rotenone-insensitive yeast -quinone oxidoreductase (Ndi1) can rescue mammalian cells from complex I dysfunction. We found that complex I inhibition provokes the following events: 1) activation of specific kinase pathways; 2) release of mitochondrial proapoptotic factors, apoptosis inducing factor, and endonuclease G. |
1(0,0,0,1) | Details |